Processed Meat and Colorectal Cancer Risk: A Pooled Analysis of Three Italian Case-Control Studies
Rosato V, Tavani A, Negri E, Serraino D, Montella M, Decarli A, La Vecchia C, Ferraroni M
Nutrition and cancer · 8 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2017-04-20 · Nutr Cancer · vol. 69 · issue 5 · pp. 732–738
- Publisher
- Routledge
- Cited
- 11 citations · more than 83% of similar papers · 1.4× the field average
- References
- 24 works
- Access
- Paywalled
- Research areas
- Nutritional Studies and Diet · Consumer Attitudes and Food Labeling · Colorectal Cancer Screening and Detection
- Keywords
- Colorectal cancer, Pooled analysis, Medicine, Case-control study, Environmental health, Oncology, Cancer, Internal medicine, Meta-analysis
- MeSH
- humans, colorectal neoplasms, logistic models, odds ratio, case-control studies, food handling, meat, adult, aged, middle aged, italy, female, male
8 authors
From IT
- Valentina RosatoUniversity of Milan
- Alessandra Tavani
- Eva NegriUniversity of Milan
- Diego SerrainoCentro di Riferimento Oncologico
- Maurizio MontellaIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
- Adriano DecarliUniversity of Milan
Abstract
To add evidence to the limited data available from southern Europe, we assessed the association between processed meat consumption and colorectal cancer risk. We analyzed data from three case-control studies conducted between 1985 and 2010 in various Italian areas, including a total of 3745 incident cases and 6804 hospital-based controls. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) by unconditional multiple logistic regression models. The median consumption of processed meat was around 20 g/day both in cases and controls. The OR of colorectal cancer was 1.02 (95% CI 0.99-1.04) for an increase of 10 g/day of processed meat. The association was statistically significant for colon cancer (OR 1.03, 95% CI 1.00-1.06), particularly for proximal colon cancer (OR 1.09, 95% CI 1.04-1.14), while there was no relation with rectal cancer (OR 0.99, 95% CI 0.95-1.03). The OR of proximal colon cancer was 1.38 (95% CI 1.08-1.75) for the highest sex-specific tertile of consumption (>25 g/day for men, >21.5 for women) compared with the lowest (<15 g/day), whereas no significant ORs were found for other anatomical subsites. Our findings indicate that there is no association with colorectal cancer overall, in the presence, however, of a positive association with proximal colon cancer.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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