Funded in part by Sanofi
The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review
Boyle NB, Lawton C, Dye L
Nutrients · 89 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Systematic review (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Company
- Sanofi
- Government
- European Food Safety Authority
- Authors
- At least one author declares a financial tie to industry
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-04-26 · Nutrients · vol. 9 · issue 5 · p. 429
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 161 citations · more than 84% of similar papers · 1.0× the field average
- References
- 106 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Preterm Birth and Chorioamnionitis · Menstrual Health and Disorders
- Keywords
- Anxiety, Medicine, CINAHL, Clinical psychology, MEDLINE, Systematic review, Randomized controlled trial, Population, Psychological intervention, Meta-analysis, Psychiatry, Internal medicine
- MeSH
- humans, magnesium, anxiety, dietary supplements, stress, physiological
3 authors
From GB
- Neil Bernard BoyleUniversity of Leeds
- Clare Louise LawtonUniversity of Leeds
- Louise DyeUniversity of Leeds
Abstract
Background
Anxiety related conditions are the most common affective disorders present in the general population with a lifetime prevalence of over 15%. Magnesium (Mg) status is associated with subjective anxiety, leading to the proposition that Mg supplementation may attenuate anxiety symptoms. This systematic review examines the available evidence for the efficacy of Mg supplementation in the alleviation of subjective measures of anxiety and stress.
Methods
A systematic search of interventions with Mg alone or in combination (up to 5 additional ingredients) was performed in May 2016. Ovid Medline, PsychInfo, Embase, CINAHL and Cochrane databases were searched using equivalent search terms. A grey literature review of relevant sources was also undertaken.
Results
18 studies were included in the review. All reviewed studies recruited samples based upon an existing vulnerability to anxiety: mildly anxious, premenstrual syndrome (PMS), postpartum status, and hypertension. Four/eight studies in anxious samples, four/seven studies in PMS samples, and one/two studies in hypertensive samples reported positive effects of Mg on subjective anxiety outcomes. Mg had no effect on postpartum anxiety. No study administered a validated measure of subjective stress as an outcome.
Conclusions
Existing evidence is suggestive of a beneficial effect of Mg on subjective anxiety in anxiety vulnerable samples. However, the quality of the existing evidence is poor. Well-designed randomised controlled trials are required to further confirm the efficacy of Mg supplementation.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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