Dose-response relationship between dietary magnesium intake, serum magnesium concentration and risk of hypertension: a systematic review and meta-analysis of prospective cohort studies
Han H, Fang X, Wei X, Liu Y, Jin Z, Chen Q, Fan Z, Aaseth J, Hiyoshi A, He J, Cao Y
Nutrition journal · 106 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- University or hospital
- Örebro Universitet
- University or hospital
- Karolinska Institutet
- University or hospital
- Second Military Medical University
- Government
- Chinese Fourth Round of the Three-year Action Plan on Public Health Discipline and Talent Program
- Grants
- Karolinska Institutet (C62412022)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-05-05 · Nutr J · vol. 16 · issue 1 · p. 26
- Publisher
- BioMed Central
- Cited
- 166 citations · more than 90% of similar papers · 1.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 64 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Sodium Intake and Health
- Keywords
- Medicine, Prospective cohort study, Magnesium, Relative risk, Cohort study, Internal medicine, Meta-analysis, Cochrane Library, Cohort, Magnesium deficiency (plants), Risk factor, Confidence interval, Endocrinology
- MeSH
- hypertension, magnesium, risk factors, blood pressure, dose-response relationship, drug, databases, factual, recommended dietary allowances
11 authors
From CN, SE, NO
- Hedong HanSecond Military Medical University
- Xin Lei Fang · correspondingKarolinska Institutet
- Xin Wei
- Yuzhou Liu
- Zhicao JinSecond Military Medical University
- Qi ChenSecond Military Medical University
Abstract
Background
The findings of prospective cohort studies are inconsistent regarding the association between dietary magnesium intake and serum magnesium concentration and the risk of hypertension. We aimed to review the evidence from prospective cohort studies and perform a dose-response meta-analysis to investigate the relationship between dietary magnesium intake and serum magnesium concentrations and the risk of hypertension.
Methods
We searched systematically PubMed, EMBASE and the Cochrane Library databases from October 1951 through June 2016. Prospective cohort studies reporting effect estimates with 95% confidence intervals (CIs) for hypertension in more than two categories of dietary magnesium intake and/or serum magnesium concentrations were included. Random-effects models were used to combine the estimated effects.
Results
Nine articles (six on dietary magnesium intake, two on serum magnesium concentration and one on both) of ten cohort studies, including 20,119 cases of hypertension and 180,566 participates, were eligible for inclusion in the meta-analysis. We found an inverse association between dietary magnesium intake and the risk of hypertension [relative risk (RR) = 0.92; 95% CI: 0.86, 0.98] comparing the highest intake group with the lowest. A 100 mg/day increment in magnesium intake was associated with a 5% reduction in the risk of hypertension (RR = 0.95; 95% CI: 0.90, 1.00). The association of serum magnesium concentration with the risk of hypertension was marginally significant (RR = 0.91; 95% CI: 0.80, 1.02).
Conclusions
Current evidence supports the inverse dose-response relationship between dietary magnesium intake and the risk of hypertension. However, the evidence about the relationship between serum magnesium concentration and hypertension is limited.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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