Effect of Magnesium Supplementation on Plasma C-reactive Protein Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Simental-Mendia LE, Sahebkar A, Rodriguez-Moran M, Zambrano-Galvan G, Guerrero-Romero F
Current pharmaceutical design · 60 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2017-05-26 · Curr Pharm Des · vol. 23 · issue 31 · pp. 4678–4686
- Publisher
- Bentham Science Publishers
- Cited
- 83 citations · more than 79% of similar papers · 0.8× the field average
- References
- 0 works
- Access
- Paywalled
- Research areas
- Magnesium in Health and Disease · Adipokines, Inflammation, and Metabolic Diseases · Therapeutic Uses of Natural Elements
- Keywords
- Meta-analysis, Randomized controlled trial, Medicine, C-reactive protein, Magnesium, Internal medicine, Gastroenterology, Subgroup analysis, Publication bias, Random effects model, Strictly standardized mean difference, Inflammation, Chemistry
- MeSH
- humans, inflammation, magnesium, c-reactive protein, dietary supplements, randomized controlled trials as topic
5 authors
From MX, IR
- Luis E. Simental‐MendíaMexican Social Security Institute
- Amirhossein SahebkarMashhad University of Medical Sciences; Biotechnology Research Center
- Martha Rodríguez‐MoránMexican Social Security Institute
- Graciela Zambrano-GalvánUniversidad Juárez del Estado de Durango
- Fernando Guerrero‐Romero · correspondingMexican Social Security Institute
Abstract
Background
Results of previous clinical trials evaluating the effect of magnesium supplementation on inflammatory markers are controversial.
Objective
A systematic review and meta-analysis of randomized controlled trials (RCTs) were performed to evaluating the effect of oral magnesium supplementation on plasma C-reactive protein (CRP) concentrations.
Method
PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases were searched (from inception to August 09, 2016) to identify RCTs, evaluating the effect of magnesium on CRP levels. A random-effects model and a generic inverse variance method were used to compensate for the heterogeneity of studies. Publication bias, sensitivity analysis, and meta-regression assessments were conducted using standard methods.
Results
Overall, the impact of magnesium supplementation on plasma concentrations of CRP was assessed in 11 studies. Magnesium treatment was not found to significantly affect plasma concentrations of CRP (WMD: -0.11 mg/L, 95% CI: -0.75, 0.52, p=0.727). When the analysis was stratified to compare subgroups of studies in populations with baseline plasma CRP values of ≤ 3 and > 3 mg/L, a significant reduction of CRP values was observed in the latter subgroup (WMD: -1.12 mg/L, 95% CI: -2.05, -0.18, p=0.019) but not in the former group (WMD: 0.61 mg/L, 95% CI: -0.10, 1.32, p=0.090). The difference between subgroups was statistically significant (p=0.004).
Conclusion
Results of the present meta-analysis indicated that magnesium supplementation reduces CRP levels among individuals with inflammation (CRP levels > 3 mg/dL). This finding suggests that magnesium supplements may have a beneficial role as an adjuvant for the management of low-grade chronic systemic inflammation.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.