No impact of fish oil supplements on bleeding risk: a systematic review
Begtrup KM, Krag AE, Hvas AM
Danish medical journal · 16 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Systematic review (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2017-05-01 · Dan Med J · vol. 64 · issue 5
- Publisher
- National Institutes of Health
- Cited
- 35 citations · more than 92% of similar papers · 2.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 0 works
- Access
- Paywalled
- Research areas
- Trauma, Hemostasis, Coagulopathy, Resuscitation · Hemostasis and retained surgical items · Fatty Acid Research and Health
- Keywords
- Medicine, Fish oil, Fish <Actinopterygii>, MEDLINE, Environmental health, Fishery
- MeSH
- humans, blood loss, surgical, postoperative hemorrhage, fish oils, risk assessment, dietary supplements, randomized controlled trials as topic
3 authors
- Katrine Munk Begtrup
- Andreas Engel Krag
- Anne‐Mette Hvas
Abstract
Introduction
Fish oil supplementation may inhibit platelet aggregation and can potentially increase the risk of bleeding. The aim of the present systematic review was to evaluate the effect of fish oil supplements on haemostasis and bleeding risk, and to provide recommendations on whether it is necessary to discontinue fish oil supplementation prior to surgery.
Methods
Studies were identified through PubMed and Embase searches and by reviewing the reference lists of the included papers. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used. Included in the review were publications including a minimum of 20 healthy subjects and studies on patients who were undergoing surgery and who had fish oil exposure.
Results
In total, 52 publications were included; 32 publications on healthy subjects and 20 publications on patients undergoing surgery. The majority of the included studies were randomised controlled trials or included a control group. Overall, fish oil supplements reduced platelet aggregation in healthy subjects. Fish oil exposure in surgical patients did not increase bleeding or blood transfusions either during or after surgery.
Conclusion
Fish oil supplements reduced platelet aggregation in healthy subjects. This biochemical effect was not reflected in increased bleeding risk during or after surgery evaluated in randomised controlled trials. Consequently, this systematic review does not support the need for discontinuation of fish oil supplements prior to surgery or other invasive procedures.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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