Dietary nitrate does not modify blood pressure and cardiac output at rest and during exercise in older adults: a randomised cross-over study
Oggioni C, Jakovljevic DG, Klonizakis M, Ashor AW, Ruddock A, Ranchordas M, Williams E, Siervo M
International journal of food sciences and nutrition · 23 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- Newcastle University
- Government
- Medical Research Council
- Government
- MRC – Arthritis Research
- University or hospital
- Sheffield University of Sheffield
- Grants
- Medical Research Council (MR/N007921/1); Medical Research Council (MR/K006312/1); Medical Research Council (MR/L016354/1)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-05-31 · Int J Food Sci Nutr · vol. 69 · issue 1 · pp. 74–83
- Publisher
- Taylor & Francis
- Cited
- 30 citations · more than 85% of similar papers · 1.7× the field average
- References
- 36 works
- Access
- Open access (repository copy)
- Research areas
- Cardiovascular Health and Disease Prevention · Cardiovascular and exercise physiology · Nitric Oxide and Endothelin Effects
- Keywords
- Medicine, Placebo, Blood pressure, Oxidative stress, Internal medicine, Cardiac function curve, Cardiology, Diastole, Inflammation, Physiology, Physical therapy, Randomized controlled trial, Pathology, Heart failure
- MeSH
- humans, beta vulgaris, plant roots, nitrates, cardiac output, exercise test, anthropometry, exercise, diet, cross-over studies, double-blind method, life style, blood pressure, aged, middle aged, female, male, gas chromatography-mass spectrometry, biomarkers, surveys and questionnaires, fruit and vegetable juices
8 authors
From GB
- Clio OggioniNewcastle University
- Djordje G. JakovljevićNewcastle University
- Markos KlonizakisSheffield Hallam University
- Ammar Waham AshorNewcastle University
- Alan D. RuddockSheffield Hallam University
- Mayur Krachna RanchordasSheffield Hallam University
Abstract
Dietary nitrate (NO3-) supplementation has been associated with improved vascular and metabolic health. We conducted a double-blind, cross-over, placebo-controlled RCT to investigate the effects of 7-d consumption of beetroot juice compared with placebo on (1) blood pressure (BP) measured in resting conditions and during exercise, (2) cardiac and peripheral vascular function and (3) biomarkers of inflammation, oxidative stress and endothelial integrity. Twenty non-smoking healthy participants aged 60-75 years and BMI 20.0-29.9 kg/m2 were recruited. Measurement was conducted before and after each 7-d intervention period. Consumption of NO3- had no effect on resting systolic and diastolic BP. NO3- consumption did not improve indexes of central and peripheral cardiac function responses during cardiopulmonary exercise testing. Dietary NO3- supplementation did not modify biomarkers of inflammation, oxidative stress and endothelial integrity. This study does not support the short-term benefits of dietary NO3- supplementation on physiological and biochemical markers of vascular health in older healthy adults.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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