Effect of age, diet, and tissue type on PCr response to creatine supplementation
Solis MY, Artioli GG, Otaduy MCG, Leite CDC, Arruda W, Veiga RR, Gualano B
Journal of applied physiology (Bethesda, Md. : 1985) · 42 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Government
- São Paulo Research Foundation (FAPESP)
- Grants
- Fundação de Amparo à Pesquisa do Estado de São Paulo (2014/06911-9)
Based on 2 listed funder(s).
Publication
- Published
- 2017-06-01 · J Appl Physiol (1985) · vol. 123 · issue 2 · pp. 407–414
- Publisher
- American Physiological Society
- Cited
- 69 citations · more than 82% of similar papers · 1.7× the field average
- References
- 52 works
- Access
- Free to read
- Research areas
- Muscle metabolism and nutrition · Obesity, Physical Activity, Diet · Sports Performance and Training
- Keywords
- Creatine, Phosphocreatine, Internal medicine, Omnivore, Creatine kinase, Endocrinology, Muscle tissue, Placebo, Medicine, Biology, Physiology, Energy metabolism, Pathology
- MeSH
- muscle, skeletal, brain, humans, creatine, phosphocreatine, magnetic resonance spectroscopy, diet, single-blind method, dietary supplements, adult, aged, child, female, male
7 authors
From BR, GB
- Marina Yázigi SolisUniversidade de São Paulo
- Guilherme Giannini ArtioliUniversidade de São Paulo; Nottingham Trent University
- Maria Concepción García OtaduyUniversidade de São Paulo
- Cláudia da Costa LeiteUniversidade de São Paulo
- Walquiria ArrudaCentro Universitário das Faculdades Metropolitanas Unidas
- Raquel Ramos VeigaCentro Universitário das Faculdades Metropolitanas Unidas
Abstract
Creatine/phosphorylcreatine (PCr) responses to creatine supplementation may be modulated by age, diet, and tissue, but studies assessing this possibility are lacking. Therefore we aimed to determine whether PCr responses vary as a function of age, diet, and tissue. Fifteen children, 17 omnivorous and 14 vegetarian adults, and 18 elderly individuals ("elderly") participated in this study. Participants were given placebo and subsequently creatine (0.3 g·kg-1·day-1) for 7 days in a single-blind fashion. PCr was measured through phosphorus magnetic resonance spectroscopy (31P-MRS) in muscle and brain. Creatine supplementation increased muscle PCr in children (P P P = 0.3348). Elderly had greater PCr increases than children and omnivores (P P = 0.0022). In relation to diet, vegetarians (P P -1·day-1 for 7 days) may be affected by age, diet, and tissue. Whereas creatine supplementation was able to increase muscle PCr in all groups, although to different extents, brain PCr was shown to be unresponsive overall. These findings demonstrate the need to tailor creatine protocols to optimize creatine/PCr accumulation both in muscle and in brain, enabling a better appreciation of the pleiotropic properties of creatine.NEW & NOTEWORTHY A standardized creatine supplementation protocol (0.3 g·kg-1·day-1 for 7 days) effectively increased muscle, but not brain, phosphorylcreatine. Older participants responded better than younger participants whereas vegetarians responded better than omnivores. Responses to supplementation are thus dependent on age, tissue, and diet. This suggests that a single "universal" protocol, originally designed for increasing muscle creatine in young individuals, may lead to heterogeneous muscle responses in different populations or even no responses in tissues other than skeletal muscle.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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