The effectiveness of creatine treatment for Parkinson's disease: an updated meta-analysis of randomized controlled trials
Mo JJ, Liu LY, Peng WB, Rao J, Liu Z, Cui LL
BMC neurology · 19 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Natural Science Foundation of Guangdong Province
- Government
- Science and Technology Planning Project of Zhanjiang
- Government
- Project of Dongguan
- Grants
- Natural Science Foundation of Guangdong Province (2014A030313541); National Natural Science Foundation of China (81400986)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-06-02 · BMC Neurol · vol. 17 · issue 1 · p. 105
- Publisher
- BioMed Central
- Cited
- 31 citations · more than 27% of similar papers · 0.2× the field average
- References
- 31 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Muscle metabolism and nutrition · Parkinson's Disease Mechanisms and Treatments · Nutrition and Health in Aging
- Keywords
- Medicine, Meta-analysis, Neurochemistry, Neurology, Randomized controlled trial, Parkinson's disease, Neurosurgery, Creatine, Physical therapy, Disease, Internal medicine, Physical medicine and rehabilitation, Intensive care medicine, Surgery, Psychiatry
- MeSH
- humans, parkinson disease, creatine, treatment outcome, activities of daily living, randomized controlled trials as topic
6 authors
From CN
- Jiajie MoGuangdong Medical College
- Lin-Ying LiuChenzhou First People's Hospital
- Wei-Bin PengGuangzhou Medical University
- Jie RaoWuhan University; Renmin Hospital of Wuhan University
- Zhou Liu · correspondingGuangdong Medical College
- Lili Cui · correspondingGuangdong Medical College
Abstract
Background
The effectiveness of creatine in treating Parkinson's disease (PD) has not been conclusively determined. Therefore, we performed a meta-analysis to address this issue.
Methods
The Cochrane Central Register of Controlled Trials, PUBMED, EMBASE, and other databases were searched, and outcomes measured by the Total Unified Parkinson's Disease Rating Scale (UPDRS) and the Schwab & England Scale were analyzed.
Results
Five randomized controlled trials (RCTs) were selected, and 1339 participants were included in the analysis. There were no significant differences between the control and treatment groups in the total, mental, activities of daily living (ADL), or motor UPDRS scores, but an improvement in Schwab & England Scale scores was observed.
Conclusions
Creatine has no observed benefit in PD patients, although more correlated studies are still needed.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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