Funded in part by Novo Nordisk Fonden
Effect of increased water intake on plasma copeptin in healthy adults
Lemetais G, Melander O, Vecchio M, Bottin JH, Enhörning S, Perrier ET
European journal of nutrition · 49 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Company
- Novo Nordisk Fonden
- Authors
- At least one author declares a financial tie to industry
- Grants
- Novo Nordisk Fonden (NNF14OC0009819); Novo Nordisk Fonden (NNF13OC0005339)
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-06-03 · Eur J Nutr · vol. 57 · issue 5 · pp. 1883–1890
- Publisher
- Springer Science+Business Media
- Cited
- 64 citations · more than 96% of similar papers · 5.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 32 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Electrolyte and hormonal disorders · Hormonal Regulation and Hypertension · Ion Transport and Channel Regulation
- Keywords
- Copeptin, Urine osmolality, Urine, Internal medicine, Medicine, Urine specific gravity, Endocrinology, Plasma osmolality, Osmole, Creatinine, Urinalysis, Renal function, Diabetes mellitus, Vasopressin
- MeSH
- humans, glycopeptides, urinalysis, prospective studies, drinking, osmolar concentration, adult, france, female, male
6 authors
From FR, SE
- Guillaume LemetaisDanone (France)
- Olle MelanderLund University; Skåne University Hospital
- Mariacristina VecchioDanone (France)
- Jeanne H. BottinDanone (France)
- Sofia EnhörningLund University; Skåne University Hospital
- Erica T. Perrier · correspondingDanone (France)
Abstract
Purpose
Inter-individual variation in median plasma copeptin is associated with incident type 2 diabetes mellitus, progression of chronic kidney disease, and cardiovascular events. In this study, we examined whether 24-h urine osmolality was associated with plasma copeptin and whether increasing daily water intake could impact circulating plasma copeptin.
Methods
This trial was a prospective study conducted at a single investigating center. Eighty-two healthy adults (age 23.6 ± 2.9 years, BMI 22.2 ± 1.5 kg/m2, 50% female) were stratified based upon habitual daily fluid intake volumes: arm A (50-80% of EFSA dietary reference values), arm B (81-120%), and arm C (121-200%). Following a baseline visit, arms A and B increased their water intake to match arm C for a period of 6 consecutive weeks.
Results
At baseline, plasma copeptin was positively and significantly associated with 24-h urine osmolality (p = 0.002) and 24-h urine specific gravity (p = 0.003) but not with plasma osmolality (p = 0.18), 24-h urine creatinine (p = 0.09), and total fluid intake (p = 0.52). Over the 6-week follow-up, copeptin decreased significantly from 5.18 (3.3;7.4) to 3.90 (2.7;5.7) pmol/L (p = 0.012), while urine osmolality and urine specific gravity decreased from 591 ± 206 to 364 ± 117 mOsm/kg (p < 0.001) and from 1.016 ± 0.005 to 1.010 ± 0.004 (p < 0.001), respectively.
Conclusions
At baseline, circulating levels of copeptin were positively associated with 24-h urine concentration in healthy young subjects with various fluid intakes. Moreover, this study shows, for the first time, that increased water intake over 6 weeks results in an attenuation of circulating copeptin.
Clinical trial registration number
NCT02044679.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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