Dietary Red and Processed Meat Intake and Markers of Adiposity and Inflammation: The Multiethnic Cohort Study
Chai W, Morimoto Y, Cooney RV, Franke AA, Shvetsov YB, Le Marchand L, Haiman CA, Kolonel LN, Goodman MT, Maskarinec G
Journal of the American College of Nutrition · 84 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Nonprofit
- American Institute for Cancer Research
- University or hospital
- University of Southern California
- Nonprofit
- World Cancer Research Fund
- Government
- National Cancer Institute
- Government
- NCI NIH HHS
- Grants
- National Cancer Institute (UM1 CA164973); National Cancer Institute (R01CA063464); National Cancer Institute (R37 CA054281); National Cancer Institute (P01 CA168530); National Cancer Institute (P30CA071789); National Cancer Institute (P01 CA033619); National Cancer Institute (P01CA138338); National Cancer Institute (R01 CA054281)
Based on 5 listed funder(s).
Publication
- Published
- 2017-06-19 · J Am Coll Nutr · vol. 36 · issue 5 · pp. 378–385
- Publisher
- Taylor & Francis
- Cited
- 112 citations · more than 96% of similar papers · 6.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 34 works
- Access
- Open access (repository copy)
- Research areas
- Nutritional Studies and Diet · Regulation of Appetite and Obesity · Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- Adiponectin, Medicine, Red meat, Leptin, Body mass index, Internal medicine, Biomarker, Endocrinology, Adipokine, Mediation, Cohort, C-reactive protein, Cohort study, Inflammation, Obesity, Insulin resistance, Biology
- MeSH
- humans, inflammation, diet, cohort studies, meat products, aged, aged, 80 and over, middle aged, female, male, adiposity, red meat, ethnicity
10 authors
From US
- Weiwen Chai · correspondingUniversity of Nebraska–Lincoln
- Yukiko MorimotoUniversity of Hawaiʻi at Mānoa; University of Hawaii System; Cancer Center of Hawaii; University of Hawaii Cancer Center
- Robert V. CooneyUniversity of Hawaiʻi at Mānoa; University of Hawaii System
- Adrian A. FrankeUniversity of Hawaiʻi at Mānoa; University of Hawaii System; Cancer Center of Hawaii; University of Hawaii Cancer Center
- Yurii B. ShvetsovUniversity of Hawaiʻi at Mānoa; University of Hawaii System; Cancer Center of Hawaii; University of Hawaii Cancer Center
- Loı̈c Le MarchandUniversity of Hawaiʻi at Mānoa; University of Hawaii System; Cancer Center of Hawaii; University of Hawaii Cancer Center
Abstract
Objective
The potential influence of dietary factors on inflammation is important for cancer prevention. Utilizing data from control participants (312 men, 911 women) in 2 nested case-control studies of cancer within the Multiethnic Cohort, we examined the associations of red and processed meat intake with serum levels of leptin, adiponectin, C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 and the mediator effect of body mass index (BMI) on the above associations (if present).
Methods
Multivariable linear models were applied to assess the association between red and processed meat intake at cohort entry and serum biomarker levels measured 9.1 years later after adjusting for covariates and to determine the mediator effect of BMI.
Results
Overall red and processed meat intake was positively associated with serum leptin levels in men (β = 0.180, p = 0.0004) and women (β = 0.167, p 0.05), whereas BMI remained significantly associated with serum leptin (men: β = 3.209, p < 0.0001; women: β = 2.891, p < 0.0001), adiponectin (women: β = -1.085, p < 0.0001), and CRP (women: β = 1.581, p < 0.0001).
Conclusion
The current data suggest that the amount of excess body weight or the degree of adiposity may mediate the relations between dietary red and processed meat intake and serum biomarkers associated with obesity and inflammation.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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