ACTH, Cortisol and IL-6 Levels in Athletes following Magnesium Supplementation
Dmitrašinović G, Pešić V, Stanić D, Plećaš-Solarović B, Dajak M, Ignjatović S
Journal of medical biochemistry · 17 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2016-06-15 · J Med Biochem · vol. 35 · issue 4 · pp. 375–384
- Publisher
- De Gruyter
- Cited
- 27 citations · more than 82% of similar papers · 1.6× the field average
- References
- 41 works
- Access
- Open access (free to publish) · CC-BY-NC-ND
- Research areas
- Magnesium in Health and Disease · Exercise and Physiological Responses · High Altitude and Hypoxia
- Keywords
- Medicine, Internal medicine, Endocrinology, Morning, Basal (medicine), Blood sampling, Saliva, Magnesium, Chemistry
6 authors
From RS
- Gordana DmitrašinovićUniversity of Belgrade
- Vesna PešićUniversity of Belgrade
- Dušanka StanićUniversity of Belgrade
- Bosiljka Plećaš‐SolarovićUniversity of Belgrade
- Marijana DajakCentar za Promociju Nauke
- Svetlana IgnjatovićUniversity of Belgrade; Centar za Promociju Nauke
Abstract
Background
Physical exercise activates the hypothalamo-pituitary-adrenal (HPA) axis and induces the body's inflammatory response. Due to contemporary dietary habits and increased energy expenditure, athletes are susceptible to depletion of magnesium ions. The aim of our study was to investigate, through assessment of plasma ACTH, serum IL-6, and salivary/serum cortisol levels, if chronic magnesium supplementation might reduce damaging stress effects in amateur rugby players.
Methods
Rugby players (N=23) were randomly assigned to intervention and control group. Basal samples were collected before intervention group started a 4-week-long supplementation with magnesium (500 mg Mg/d). Blood and saliva sampling were done a day before the match (Day-1), on the morning of competition (Game), and during a six-day-long recovery period (Day1, Day3 and Day6). ACTH, serum/salivary cortisol, IL-6 and total/differential leukocytes counts were determined at each time point.
Results
There was a statistically significant increase in ACTH concentration in intervention group compared to control group, while reductions in cortisol concentrations between the two groups were the greatest at Day-1 (p < 0.01) and at the day of competition (Game) (p < 0.01). Our results revealed that magnesium completely abolished the increase in IL-6 level noted in control group on Day1 and Day3 vs. Day-1 (p < 0.01) and also diminished the rise in neutrophil/lymphocyte ratio in intervention group vs. control group (p < 0.01).
Conclusions
These results suggest the possibly important influence magnesium supplementation might have on the change of parameters of HPA axis activity and reduction of immune response activation following strenuous physical exercise such as a rugby game.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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