25-hydroxyvitamin D status in patients with alopecia areata
Erpolat S, Sarifakioglu E, Ayyildiz A
Postepy dermatologii i alergologii · 17 citations
How it was studied
- Design
- Case-control study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2017-01-01 · Postepy Dermatol Alergol · vol. 3 · issue 3 · pp. 248–252
- Publisher
- Termedia Publishing House
- Cited
- 29 citations · more than 94% of similar papers · 4.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 22 works
- Access
- Open access (journal)
- Research areas
- Hair Growth and Disorders · Vitamin D Research Studies · Facial Rejuvenation and Surgery Techniques
- Keywords
- Alopecia areata, Medicine, Dermatology
3 authors
From TR
- Seval ErpolatTurgut Özal University
- Evren SarıfakıoğluTurgut Özal University
- Abdullah AyyıldızTurgut Özal University
Abstract
Introduction
Alopecia areata (AA) is a T cell-mediated autoimmune disease that causes inflammation around anagen-phase hair follicles. Insufficient levels of vitamin D have been implicated in a variety of autoimmune diseases.
Aim
To investigate the status of serum 25-hydroxyvitamin D (25(OH)D) in patients with AA, serum 25(OH)D concentrations were compared between AA patients and healthy controls and thus determine if a possible association exists between serum 25(OH)D levels and AA.
Material and methods
The study comprising 41 patients diagnosed with AA and 32 healthy controls was conducted between October 2010 and March 2011. The serum vitamin D levels of the study group were determined by high performance liquid chromatography. Serum levels of calcium, phosphorus, alkaline phosphatase, and parathyroid hormone were also evaluated.
Results
The study was based on 41 patients aged between 20 and 50 (mean: 32.8 ±7.5). The control group included 32 healthy persons aged between 20 and 51 (mean: 32.7 ±7.5). Serum 25(OH)D levels in patients with AA ranged from 5.0 to 38.6 ng/ml with a mean of 8.1 ng/ml. Serum 25(OH)D levels in healthy controls ranged from 3.6 to 38.5 ng/ml with a mean of 9.8 ng/ml. There was no statistically significant difference in the serum vitamin D level between AA patients and healthy controls (p > 0.05).
Conclusions
Deficient serum 25(OH)D levels are present in patients with AA. However, considering the high prevalence of vitamin D deficiency in Turkey, no difference was noted between AA patients and controls.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-SA).
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