Fish oil supplementation and insulin sensitivity: a systematic review and meta-analysis
Gao H, Geng T, Huang T, Zhao Q
Lipids in health and disease · 95 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Chongqing Municipal Public Health Bureau, Chongqing People's Municipal Government
- Government
- Chongqing Municipal Public Health Bureau, Chongqing People's Municipal Government
- Grants
- Chongqing Municipal Public Health Bureau, Chongqing People's Municipal Government (2009-1-57)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-07-03 · Lipids Health Dis · vol. 16 · issue 1 · p. 131
- Publisher
- BioMed Central
- Cited
- 141 citations · more than 94% of similar papers · 1.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 53 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Fatty Acid Research and Health · Nigella sativa pharmacological applications · Antioxidant Activity and Oxidative Stress
- Keywords
- Fish oil, Meta-analysis, Clinical nutrition, Medicine, Internal medicine, Cochrane Library, Insulin, Type 2 diabetes, Insulin resistance, Diabetes mellitus, Polyunsaturated fatty acid, Subgroup analysis, Metabolic syndrome, Quantitative insulin sensitivity check index, Clinical chemistry, Insulin sensitivity, Physiology, Endocrinology, Biology, Fish <Actinopterygii>, Fatty acid, Biochemistry
- MeSH
- animals, humans, insulin resistance, fatty acids, omega-3, fish oils, databases, factual, metabolic syndrome
4 authors
From CN, SG
- Huanqing GaoChongqing Medical University
- Tingting GengThe Affiliated Yongchuan Hospital of Chongqing Medical University; Chongqing Medical University
- Tao Huang · correspondingNational University of Singapore; National University Health System
- Qinghua Zhao · correspondingThe Affiliated Yongchuan Hospital of Chongqing Medical University; Chongqing Medical University
Abstract
Background
Fish oil supplementation has been shown to be associated with a lower risk of metabolic syndrome and benefit a wide range of chronic diseases, such as cardiovascular disease, type 2 diabetes and several types of cancers. However, the evidence of fish oil supplementation on glucose metabolism and insulin sensitivity is still controversial. This meta-analysis summarized the exist evidence of the relationship between fish oil supplementation and insulin sensitivity and aimed to evaluate whether fish oil supplementation could improve insulin sensitivity.
Methods
We searched the Cochrane Library, PubMed, Embase database for the relevant studies update to Dec 2016. Two researchers screened the literature independently by the selection and exclusion criteria. Studies were pooled using random effect models to estimate a pooled SMD and corresponding 95% CI. This meta-analysis was performed by Stata 13.1 software.
Results
A total of 17 studies with 672 participants were included in this meta-analysis study after screening from 498 published articles found after the initial search. In a pooled analysis, fish oil supplementation had no effects on insulin sensitivity compared with the placebo (SMD 0.17, 95%CI -0.15 to 0.48, p = 0.292). In subgroup analysis, fish oil supplementation could benefit insulin sensitivity among people who were experiencing at least one symptom of metabolic disorders (SMD 0.53, 95% CI 0.17 to 0.88, p < 0.001). Similarly, there were no significant differences between subgroups of methods of insulin sensitivity, doses of omega-3 polyunsaturated fatty acids (n-3 PUFA) of fish oil supplementation or duration of the intervention. The sensitivity analysis indicated that the results were robust.
Conclusions
Short-term fish oil supplementation is associated with increasing the insulin sensitivity among those people with metabolic disorders.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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