Fish oil-enriched nutrition combined with systemic chemotherapy for gastrointestinal cancer patients with cancer cachexia
Shirai Y, Okugawa Y, Hishida A, Ogawa A, Okamoto K, Shintani M, Morimoto Y, Nishikawa R, Yokoe T, Tanaka K, Urata H, Toiyama Y, Inoue Y, Tanaka M, Mohri Y, Goel A, Kusunoki M, McMillan DC, Miki C
Scientific reports · 65 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2017-06-30 · Sci Rep · vol. 7 · issue 1 · p. 4826
- Publisher
- Nature Portfolio
- Cited
- 83 citations · more than 95% of similar papers · 4.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 32 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nutrition and Health in Aging · Frailty in Older Adults · GDF15 and Related Biomarkers
- Keywords
- Cachexia, Medicine, Fish oil, Gastrointestinal cancer, Chemotherapy, Bioelectrical impedance analysis, Cancer, Internal medicine, Lean body mass, Systemic inflammation, Gastroenterology, Eicosapentaenoic acid, Oncology, Inflammation, Polyunsaturated fatty acid, Colorectal cancer, Body mass index, Biology, Body weight, Fatty acid, Fish <Actinopterygii>
- MeSH
- humans, gastrointestinal neoplasms, inflammation, cachexia, dietary fats, unsaturated, eicosapentaenoic acid, fish oils, c-reactive protein, carcinoembryonic antigen, antineoplastic combined chemotherapy protocols, antigens, tumor-associated, carbohydrate, prognosis, survival analysis, cohort studies, body composition, nutritional status, aged, female, male, biomarkers, tumor
19 authors
From JP, US, GB
- Yumiko Shirai
- Yoshinaga Okugawa · correspondingMie University; Baylor University Medical Center; Baylor Scott & White Research Institute
- Asahi HishidaNagoya University
- Aki Ogawa
- Kyoko Okamoto
- Miki Shintani
Abstract
Despite recent advances in chemotherapy for gastrointestinal cancer, a crucial factor related to poor prognosis is reduced tolerance to chemotherapy induced by cancer cachexia. Fish oil (FO)-derived eicosapentaenoic acid (EPA) modulates inflammation in patients with various malignancies; however, the impact of FO-enriched nutrition as a combined modality therapy on clinical outcomes remains controversial. We systemically analysed chronological changes in biochemical and physiological status using bioelectrical impedance analysis in 128 gastrointestinal cancer patients provided with or without FO-enriched nutrition during chemotherapy. Furthermore, we evaluated the clinical significance of FO-enriched nutrition and clarified appropriate patient groups that receive prognostic benefits from FO-enriched nutrition during treatment of gastrointestinal cancer. The control group showed significant up-regulation of serum CRP) levels and no significant difference in both skeletal muscle mass and lean body mass. In contrast, the FO-enriched nutrition group showed no changes in serum CRP concentration and significantly increased skeletal muscle mass and lean body mass over time. Furthermore, high CRP levels significantly correlated with reduced tolerance to chemotherapy, and FO-enriched nutrition improved chemotherapy tolerance and prognosis, particularly in gastrointestinal cancer patients with a modified Glasgow prognostic score (mGPS) of 1 or 2. We conclude that FO-enriched nutrition may improve the prognosis of patients with cancer cachexia and systemic inflammation (i.e., those with a mGPS of 1 or 2).
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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