Funded in part by Symrise
Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells
Liszt KI, Ley JP, Lieder B, Behrens M, Stöger V, Reiner A, Hochkogler CM, Köck E, Marchiori A, Hans J, Widder S, Krammer G, Sanger GJ, Somoza MM, Meyerhof W, Somoza V
Proceedings of the National Academy of Sciences of the United States of America · 105 citations
Review labels
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How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Government
- Österreichische Nationalstiftung für Forschung, Technologie und Entwicklung
- Government
- Austrian Federal Ministry of Economy, Family and Youth
- Government
- Institut National de la Santé et de la Recherche Médicale
- Government
- Austrian Science Fund
- Company
- Symrise
- Government
- Biotechnology and Biological Sciences Research Council
- Government
- Austrian Science Fund FWF
- Government
- Medical Research Council
- Grants
- Austrian Science Fund (FWF P23797); Austrian Science Fund (P23797); Biotechnology and Biological Sciences Research Council (1507481)
Based on 8 listed funder(s).
Publication
- Published
- 2017-07-10 · Proc Natl Acad Sci U S A · vol. 114 · issue 30 · pp. E6260–E6269
- Publisher
- National Academy of Sciences
- Cited
- 139 citations · more than 98% of similar papers · 7.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 44 works
- Access
- Free to read
- Research areas
- Biochemical Analysis and Sensing Techniques · Olfactory and Sensory Function Studies · Advanced Chemical Sensor Technologies
- Keywords
- Gastric acid, Caffeine, Secretion, Taste, Bitter taste, Parietal cell, Gastric mucosa, Peptic ulcer, Internal medicine, Chemistry, Medicine, Pharmacology, Stomach, Biochemistry
- MeSH
- parietal cells, gastric, gastric acid, humans, flavones, caffeine, receptors, g-protein-coupled, taste
16 authors
From AT, DE
- Kathrin Ingrid LisztUniversity of Vienna; Christian Doppler Laboratory for Thermoelectricity
- Jakob Peter LeySymrise (Germany)
- Barbara LiederUniversity of Vienna; Christian Doppler Laboratory for Thermoelectricity
- Maik BehrensGerman Institute of Human Nutrition
- Verena StögerChristian Doppler Laboratory for Thermoelectricity
- Angelika ReinerDonauspital
Abstract
Caffeine, generally known as a stimulant of gastric acid secretion (GAS), is a bitter-tasting compound that activates several taste type 2 bitter receptors (TAS2Rs). TAS2Rs are expressed in the mouth and in several extraoral sites, e.g., in the gastrointestinal tract, in which their functional role still needs to be clarified. We hypothesized that caffeine evokes effects on GAS by activation of oral and gastric TAS2Rs and demonstrate that caffeine, when administered encapsulated, stimulates GAS, whereas oral administration of a caffeine solution delays GAS in healthy human subjects. Correlation analysis of data obtained from ingestion of the caffeine solution revealed an association between the magnitude of the GAS response and the perceived bitterness, suggesting a functional role of oral TAS2Rs in GAS. Expression of TAS2Rs, including cognate TAS2Rs for caffeine, was shown in human gastric epithelial cells of the corpus/fundus and in HGT-1 cells, a model for the study of GAS. In HGT-1 cells, various bitter compounds as well as caffeine stimulated proton secretion, whereby the caffeine-evoked effect was (i) shown to depend on one of its cognate receptor, TAS2R43, and adenylyl cyclase; and (ii) reduced by homoeriodictyol (HED), a known inhibitor of caffeine's bitter taste. This inhibitory effect of HED on caffeine-induced GAS was verified in healthy human subjects. These findings (i) demonstrate that bitter taste receptors in the stomach and the oral cavity are involved in the regulation of GAS and (ii) suggest that bitter tastants and bitter-masking compounds could be potentially useful therapeutics to regulate gastric pH.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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