Association of 25-Hydroxyvitamin D Deficiency in Pediatric Epileptic Patients
Chaudhuri JR, Mridula KR, Rathnakishore C, Balaraju B, Bandaru VS
Iranian journal of child neurology · 15 citations
How it was studied
- Design
- Case-control study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2017-01-01 · Iran J Child Neurol · vol. 11 · issue 2 · pp. 48–56
- Publisher
- National Institutes of Health
- Cited
- 40 citations · more than 94% of similar papers · 4.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 50 works
- Access
- Open access (repository copy) · CC-BY
- Research areas
- Pharmacological Effects and Toxicity Studies · Vitamin D Research Studies · Folate and B Vitamins Research
- Keywords
- Medicine, Carbamazepine, Odds ratio, Epilepsy, vitamin D deficiency, Vitamin D and neurology, Internal medicine, Gastroenterology, Pediatrics, Psychiatry
5 authors
From IN
- Jaydip Ray ChaudhuriYashoda Hospital
- Kandadai Rukmini MridulaNizam's Institute of Medical Sciences
- Chakrala Rathnakishore
- Banda BalarajuYashoda Hospital
- VCS Srinivasarao BandaruYashoda Hospital
Abstract
Objective
Epilepsy is a chronic neurological disorder requiring long-term therapy using antiepileptic medications. Reports have incriminated long-term antiepileptic drugs use in deficiency of vitamin D and bone diseases in all age groups. We aimed to investigate the association between serum 25-hydroxyvitamin D levels and pediatric epilepsy in Indian patients.
Materials & methods
We prospectively recruited 100 pediatric epilepsy patients, on monotherapy for minimum one-year duration, and 50 age and sex matched controls. This study was carried out at Yashoda Hospital, India from 2011-2014. All cases and controls underwent tests for serum 25-hydroxyvitamin D, alkaline phosphatase, serum calcium and phosphorus levels.
Results
Patients with 25-hydroxyvitamin D deficiency were significantly higher among cases (45%) than controls (24%). Mean alkaline phosphatase was significantly higher in cases and mean serum calcium was significantly lower (8.3±1.5) in cases. Amongst antiepileptic drugs, carbamazepine and sodium valproate were significantly associated with 25-hydroxyvitamin D deficiency. Risk of vitamin D deficiency was highest with sodium valproate usage (odds:4.0;95%CI 1.4-11.6) followed by carbamazepine use (odds: 2.7; 95%CI 1.0-6.8). After adjustment using multiple logistic regression, antiepileptic drugs showed independent association with 25-hydroxyvitamin D deficiency (odds:2.2;95%CI 0.9-4.5).
Conclusion
25-hydroxyvitamin D deficiency was significantly associated with use of carbamazepine and sodium valproate in pediatric epilepsy.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.