Whole Grain Intake and Glycaemic Control in Healthy Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Marventano S, Vetrani C, Vitale M, Godos J, Riccardi G, Grosso G
Nutrients · 84 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2017-07-19 · Nutrients · vol. 9 · issue 7 · p. 769
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 119 citations · more than 86% of similar papers · 1.1× the field average
- References
- 67 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Food composition and properties · Nutritional Studies and Diet · Celiac Disease Research and Management
- Keywords
- Postprandial, Medicine, Insulin, Randomized controlled trial, Insulin resistance, Meta-analysis, Glucose homeostasis, Observational study, Homeostatic model assessment, Internal medicine, Endocrinology
- MeSH
- humans, insulin resistance, insulin, blood glucose, diet, postprandial period, randomized controlled trials as topic, whole grains
6 authors
From IT
- Stefano MarventanoUniversity of Catania
- Claudia VetraniFederico II University Hospital
- Marilena Vitale · correspondingFederico II University Hospital
- Justyna GodosAzienda Ospedaliero Universitaria Policlinico "G.Rodolico - San Marco"
- Gabriele RiccardiFederico II University Hospital
- Giuseppe GrossoAzienda Ospedaliero Universitaria Policlinico "G.Rodolico - San Marco"
Abstract
Backgrounds
There is growing evidence from both observational and intervention studies that Whole Grain (WG) cereals exert beneficial effects on human health, especially on the metabolic profile. The aim of this study was to perform a meta-analysis of randomised controlled trials (RCT) to assess the acute and medium/long-term effect of WG foods on glycaemic control and insulin sensitivity in healthy individuals.
Methods
A search for all the published RCT on the effect of WG food intake on glycaemic and insulin response was performed up to December 2016. Effect size consisted of mean difference (MD) and 95% CI between the outcomes of intervention and the control groups using the generic inverse-variance random effects model.
Results
The meta-analysis of the 14 studies testing the acute effects of WG foods showed significant reductions of the post-prandial values of the glucose iAUC (0-120 min) by -29.71 mmol min/L (95% CI: -43.57, -15.85 mmol min/L), the insulin iAUC (0-120 min) by -2.01 nmol min/L (95% CI: -2.88, -1.14 nmol min/L), and the maximal glucose and insulin response. In 16 medium- and long-term RCTs, effects of WG foods on fasting glucose and insulin and homeostatic model assessment-insulin resistance values were not significant.
Conclusions
The consumption of WG foods is able to improve acutely the postprandial glucose and insulin homeostasis compared to similar refined foods in healthy subjects. Further research is needed to better understand the long-term effects and the biological mechanisms.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.