Cholecalciferol, Calcitriol, and Vascular Function in CKD: A Randomized, Double-Blind Trial
Kendrick J, Andrews E, You Z, Moreau K, Nowak KL, Farmer-Bailey H, Seals DR, Chonchol M
Clinical journal of the American Society of Nephrology : CJASN · 35 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Nonprofit
- American Society of Nephrology
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- National Center for Research Resources
- University or hospital
- Colorado Clinical and Translational Sciences Institute
- Government
- NIDDK NIH HHS
- Government
- NCRR NIH HHS
- Grants
- National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK048520); National Institute of Diabetes and Digestive and Kidney Diseases (K23-DK087859); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK099199); National Center for Research Resources (#UL1 RR025780)
Based on 6 listed funder(s).
Publication
- Published
- 2017-08-07 · Clin J Am Soc Nephrol · vol. 12 · issue 9 · pp. 1438–1446
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 44 citations · more than 96% of similar papers · 4.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 48 works
- Access
- Open access (repository copy)
- Research areas
- Vitamin D Research Studies · Parathyroid Disorders and Treatments · Nitric Oxide and Endothelin Effects
- Keywords
- Calcitriol, Cholecalciferol, Medicine, Vitamin D and neurology, Internal medicine, vitamin D deficiency, Endocrinology, Gastroenterology, Urology
- MeSH
- kidney, brachial artery, humans, cholecalciferol, calcitriol, vitamin d, inflammation mediators, glomerular filtration rate, treatment outcome, prospective studies, double-blind method, recovery of function, vasodilation, time factors, dietary supplements, aged, middle aged, colorado, female, male, renal insufficiency, chronic, biomarkers
8 authors
From US
- Jessica Kendrick · correspondingDenver Health Medical Center; University of Colorado Denver
- Emily S. Andrews · corresponding
- Zhiying You · corresponding
- Kerrie L. MoreauUniversity of Colorado Denver
- Kristen L. Nowak · corresponding
- Heather Farmer‐Bailey · corresponding
Abstract
Background and objectives
High circulating vitamin D levels are associated with lower cardiovascular mortality in CKD, possibly by modifying endothelial function. We examined the effect of calcitriol versus cholecalciferol supplementation on vascular endothelial function in patients with CKD.
Design, setting, participants, & measurements
We performed a prospective, double-blind, randomized trial of 128 adult patients with eGFR=15-44 ml/min per 1.73 m2and serum 25-hydroxyvitamin D level μg) daily for 6 months. The primary end point was change in brachial artery flow-mediated dilation. Secondary end points included changes in circulating markers of mineral metabolism and circulating and cellular markers of inflammation.
Results
One hundred and fifteen patients completed the study. The mean (SD) age and eGFR of participants were 58±12 years old and 33.0±10.2 ml/min per 1.73 m2, respectively. There were no significant differences between groups at baseline. After 6 months, neither calcitriol nor cholecalciferol treatment resulted in a significant improvement in flow-mediated dilation (mean±SD percentage flow-mediated dilation; calcitriol: baseline 4.8±3.1%, end of study 5.1±3.6%; cholecalciferol: baseline 5.2±5.2%, end of study 4.7±3.6%); 25-hydroxyvitamin D levels increased significantly in the cholecalciferol group compared with the calcitriol group (cholecalciferol: 11.0±9.5 ng/ml; calcitriol: -0.8±4.8 ng/ml; PP=0.004).
Conclusions
Six months of therapy with calcitriol or cholecalciferol did not improve vascular endothelial function or improve inflammation in patients with CKD.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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