Changes in Lipids and Inflammatory Markers after Consuming Diets High in Red Meat or Dairy for Four Weeks
Turner KM, Keogh JB, Meikle PJ, Clifton PM
Nutrients · 19 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- University of South Australia
- Government
- Medical Research Council
- Government
- National Health and Medical Research Council
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-08-17 · Nutrients · vol. 9 · issue 8 · p. 886
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 23 citations · more than 85% of similar papers · 1.8× the field average
- References
- 47 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Adipokines, Inflammation, and Metabolic Diseases · Regulation of Appetite and Obesity · Adipose Tissue and Metabolism
- Keywords
- Insulin resistance, Endocrinology, Internal medicine, Lipidomics, Insulin, Tumor necrosis factor alpha, Biology, Red meat, Phospholipid, Inflammation, Chemistry, Food science, Biochemistry, Medicine
- MeSH
- humans, insulin resistance, inflammation, cholesterol, dietary carbohydrates, dietary fats, triglycerides, phosphatidylcholines, phosphatidylethanolamines, phosphatidylinositols, tumor necrosis factor-alpha, c-reactive protein, dietary proteins, body mass index, diet, dairy products, adult, middle aged, female, male, biomarkers, red meat
4 authors
From AU
- Kirsty TurnerUniversity of South Australia
- Jennifer B KeoghUniversity of South Australia
- Peter J. MeikleBaker Heart and Diabetes Institute
- Peter Marshall Clifton · correspondingUniversity of South Australia
Abstract
There is a body of evidence linking inflammation, altered lipid metabolism, and insulin resistance. Our previous research found that insulin sensitivity decreased after a four-week diet high in dairy compared to a control diet and to one high in red meat. Our aim was to determine whether a relationship exists between changes in insulin sensitivity and inflammatory biomarkers, or with lipid species. Fasting Tumor Necrosis Factor alpha (TNF-α), Tumor Necrosis Factor Receptor II (sTNF-RII), C-reactive protein (CRP), and lipids were measured at the end of each diet. TNF-α and the ratio TNF-α/sTNF-RII were not different between diets and TNF-α, sTNF-RII, or the ratio TNF-α/sTNF-RII showed no association with homeostasis model assessment-estimated insulin resistance (HOMA-IR). A number of phosphatidylethanolamine (PE) and phosphatidylinositol (PI) species differed between dairy and red meat and dairy and control diets, as did many phosphatidylcholine (PC) species and cholesteryl ester (CE) 14:0, CE15:0, lysophosphatidylcholine (LPC) 14:0, and LPC15:0. None had a significant relationship (p = 0.001 or better) with log homeostasis model assessment-estimated insulin resistance (HOMA-IR), although LPC14:0 had the strongest relationship (p = 0.004) and may be the main mediator of the effect of dairy on insulin sensitivity. LPC14:0 and the whole LPC class were correlated with CRP. The correlations between dietary change and the minor plasma phospholipids PI32:1 and PE32:1 are novel and may reflect significant changes in membrane composition. Inflammatory markers were not altered by changes in protein source while the correlation of LPC with CRP confirms a relationship between changes in lipid profile and inflammation.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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