Coffee, Caffeine, and Health Outcomes: An Umbrella Review
Grosso G, Godos J, Galvano F, Giovannucci EL
Annual review of nutrition · 344 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2017-08-21 · Annu Rev Nutr · vol. 37 · issue 1 · pp. 131–156
- Publisher
- Annual Reviews
- Cited
- 542 citations · more than 99% of similar papers · 9.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 150 works
- Access
- Paywalled
- Research areas
- Coffee research and impacts · Obesity, Physical Activity, Diet
- Keywords
- Observational study, Medicine, Caffeine, Meta-analysis, Randomized controlled trial, Type 2 diabetes, Disease, Internal medicine, Diabetes mellitus, Endocrinology
- MeSH
- humans, neoplasms, neurodegenerative diseases, cardiovascular diseases, diabetes mellitus, type 2, caffeine, risk, pregnancy, coffee, female, male, randomized controlled trials as topic, observational studies as topic
4 authors
From IT, US
- Giuseppe GrossoUniversity of Catania
- Justyna GodosUniversity of Catania
- Fabio GalvanoUniversity of Catania
- Edward L. GiovannucciBrigham and Women's Hospital; Harvard University
Abstract
To evaluate the associations between coffee and caffeine consumption and various health outcomes, we performed an umbrella review of the evidence from meta-analyses of observational studies and randomized controlled trials (RCTs). Of the 59 unique outcomes examined in the selected 112 meta-analyses of observational studies, coffee was associated with a probable decreased risk of breast, colorectal, colon, endometrial, and prostate cancers; cardiovascular disease and mortality; Parkinson's disease; and type-2 diabetes. Of the 14 unique outcomes examined in the 20 selected meta-analyses of observational studies, caffeine was associated with a probable decreased risk of Parkinson's disease and type-2 diabetes and an increased risk of pregnancy loss. Of the 12 unique acute outcomes examined in the selected 9 meta-analyses of RCTs, coffee was associated with a rise in serum lipids, but this result was affected by significant heterogeneity, and caffeine was associated with a rise in blood pressure. Given the spectrum of conditions studied and the robustness of many of the results, these findings indicate that coffee can be part of a healthful diet.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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