A Model of Exposure to Extreme Environmental Heat Uncovers the Human Transcriptome to Heat Stress
Bouchama A, Aziz MA, Mahri SA, Gabere MN, Dlamy MA, Mohammad S, Abbad MA, Hussein M
Scientific reports · 59 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- University or hospital
- King Abdullah International Medical Research Center
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-08-21 · Sci Rep · vol. 7 · issue 1 · p. 9429
- Publisher
- Nature Portfolio
- Cited
- 89 citations · more than 76% of similar papers · 1.2× the field average
- References
- 75 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Climate Change and Health Impacts · Thermoregulation and physiological responses · Adipose Tissue and Metabolism
- Keywords
- Transcriptome, Proteostasis, Heat shock protein, Biology, Heat stress, Heat shock, Gene, Extreme heat, Gene expression, Function (biology), Cell biology, Genetics, Ecology
- MeSH
- humans, reproducibility of results, gene expression profiling, environmental exposure, signal transduction, heat-shock response, adult, female, male, young adult, extreme heat, transcriptome, biomarkers
8 authors
From SA
- Abderrezak Bouchama · correspondingKing Saud bin Abdulaziz University for Health Sciences; King Abdullah International Medical Research Center
- Mohammad Azhar AzizKing Saud bin Abdulaziz University for Health Sciences; King Abdullah International Medical Research Center
- Saeed Al MahriKing Saud bin Abdulaziz University for Health Sciences; King Abdullah International Medical Research Center
- Musa Nur GabereKing Saud bin Abdulaziz University for Health Sciences; King Abdullah International Medical Research Center
- Meshan Al DlamyKing Saud bin Abdulaziz University for Health Sciences; King Abdullah International Medical Research Center
- Sameer MohammadKing Saud bin Abdulaziz University for Health Sciences; King Abdullah International Medical Research Center
Abstract
The molecular mechanisms by which individuals subjected to environmental heat stress either recover or develop heat-related complications are not well understood. We analysed the changes in blood mononuclear gene expression patterns in human volunteers exposed to extreme heat in a sauna (temperature of 75.7 ± 0.86 °C). Our analysis reveals that expression changes occur rapidly with no significant increase in core temperature and continue to amplify one hour after the end of heat stress. The reprogramed transcriptome was predominantly inhibitory, as more than two-thirds of the expressed genes were suppressed. The differentially expressed genes encoded proteins that function in stress-associated pathways; including proteostasis, energy metabolism, cell growth and proliferation, and cell death, and survival. The transcriptome also included mitochondrial dysfunction, altered protein synthesis, and reduced expression of genes -related to immune function. The findings reveal the human transcriptomic response to heat and highlight changes that might underlie the health outcomes observed during heat waves.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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