Funded in part by Astellas Pharma
Effect of Magnesium Supplements on Insulin Secretion After Kidney Transplantation: A Randomized Controlled Trial
Van Laecke S, Caluwe R, Huybrechts I, Nagler EV, Vanholder R, Peeters P, Van Vlem B, Van Biesen W
Annals of transplantation · 19 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Government
- World Health Organization
- Company
- Astellas Pharma
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-08-29 · Ann Transplant · vol. 22 · pp. 524–531
- Publisher
- International Scientific Information Inc.
- Cited
- 21 citations · more than 85% of similar papers · 1.9× the field average
- References
- 28 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Potassium and Related Disorders
- Keywords
- Hypomagnesemia, Medicine, Internal medicine, Endocrinology, Transplantation, Insulin, Insulin resistance, Glycemic, Diabetes mellitus, Magnesium deficiency (plants), Kidney transplantation, Magnesium, Chemistry
- MeSH
- humans, magnesium, tacrolimus, insulin, blood glucose, immunosuppressive agents, treatment outcome, kidney transplantation, graft rejection, dietary supplements, adult, aged, middle aged, female, male, insulin secretion, glycated hemoglobin
8 authors
From BE
- Steven Van Laecke · correspondingGhent University Hospital
- Rogier CaluwéOnze Lieve Vrouwziekenhuis Hospital
- Inge HuybrechtsGhent University
- Evi Vanessa NaglerGhent University Hospital
- Raymond Camille VanholderGhent University Hospital
- Patrick C. PeetersGhent University Hospital
Abstract
BACKGROUND Hypomagnesemia is associated with a disturbed glucose metabolism. Insulin hypo-secretion predicts diabetes in the general population and in transplant recipients. We aimed to assess whether magnesium improves insulin secretion and glycemic control after transplantation in prevalent hypomagnesemic kidney transplant recipients. MATERIAL AND METHODS We conducted an open-label, randomized, parallel-group study. Eligible participants were adults more than 4 months after kidney transplantation on tacrolimus with persisting serum magnesium concentrations <1.8 mg/dL randomized to magnesium oxide supplementation up to a maximum of 3 times 450 mg daily (N=26) or no supplements (N=26). Insulin secretion was assessed by OGTT-derived, first-phase insulin secretion (FPIR). The primary endpoint was the mean difference in FPIR between baseline and 6 months after randomization. Secondary endpoints were differences in HbA1c and insulin resistance, measured by HOMA. Dietary magnesium was assessed by a food-frequency questionnaire. All analyses were done on an intention-to-treat basis. RESULTS Magnesium with a mean daily dose of 688±237mg in the treatment group failed to lead to significant differences between the 2 groups in FPIR, fasting glucose, HbA1c, or HOMA-IR. Persisting hypomagnesemia was very common and associated with more insulin hypo-secretion, glucose intolerance, and lower dietary magnesium intake (142±56 versus 202±90 mg; p=0.015) as compared to patients with a rise in serum magnesium over 6 months. CONCLUSIONS Magnesium supplementation does not improve insulin secretion in stable hypomagnesemic kidney transplant recipients on tacrolimus. Persisting hypomagnesemia is associated with impaired glucose tolerance, insulin hypo-secretion, and dietary factors.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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