Coffee with High but Not Low Caffeine Content Augments Fluid and Electrolyte Excretion at Rest
Seal AD, Bardis CN, Gavrieli A, Grigorakis P, Adams JD, Arnaoutis G, Yannakoulia M, Kavouras SA
Frontiers in nutrition · 42 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Authors
- At least one author declares a financial tie to industry
Based on full-text disclosure statement.
Publication
- Published
- 2017-08-18 · Front Nutr · vol. 4 · p. 40
- Publisher
- Frontiers Media
- Cited
- 57 citations · more than 88% of similar papers · 2.5× the field average
- References
- 31 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Coffee research and impacts · Diet and metabolism studies
- Keywords
- Caffeine, Ingestion, Excretion, Crossover study, Fluid intake, Animal science, Urine, Morning, Chemistry, Diuresis, Diuretic, Dehydration, Saliva, Medicine, Internal medicine, Endocrinology, Placebo, Biology, Biochemistry, Renal function
8 authors
From US, GR
- Adam SealUniversity of Arkansas at Fayetteville
- Costas N. BardisHarokopio University of Athens
- Anna GavrieliHarokopio University of Athens
- Petros GrigorakisHarokopio University of Athens
- J.D. AdamsUniversity of Arkansas at Fayetteville
- Giannis ArnaoutisHarokopio University of Athens
Abstract
Background
Low levels of caffeine ingestion do not induce dehydration at rest, while it is not clear if larger doses do have an acute diuretic effect. The aim of the present investigation was to examine the acute effect of low and high levels of caffeine, via coffee, on fluid balance in habitual coffee drinkers (at least one per day) at rest.
Methods
Ten healthy adults (eight males and two females; age: 27 ± 5 years, weight: 89.5 ± 14.8 kg, height: 1.75 ± 0.08 m, and body mass index: 29.1 ± 4.4 kg m-2) ingested 200 mL of water (W), coffee with low caffeine (3 mg kg-1, LCAF), or coffee with high caffeine (6 mg kg-1, HCAF) on three respective separate occasions. All sessions were performed at 09:00 in the morning in a counterbalanced, crossover manner, at least 5 days apart. Subjects remained in the laboratory while urine samples were collected every 60 min for 3 h post ingestion.
Results
Absolute caffeine consumption was 269 ± 45 and 537 ± 89 mg for the LCAF and HCAF, respectively. Coffee ingestion at the HCAF trial induced greater diuresis during the 3-h period (613 ± 101 mL, P P < 0.05), as compared to the W (249 ± 36 mmol) and LCAF (177 ± 16 mmol) trials.
Conclusion
The data indicate that caffeine intake of 6 mg kg-1 in the form of coffee can induce an acute diuretic effect, while 3 mg kg-1 do not disturb fluid balance in healthy casual coffee drinking adults at rest.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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