Potential Application of Eicosapentaenoic Acid Monoacylglyceride in the Management of Colorectal Cancer
Morin C, Rodríguez E, Blier PU, Fortin S
Marine drugs · 16 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- People, plus animal or lab work
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Authors
- At least one author declares a financial tie to industry
Based on full-text disclosure statement.
Publication
- Published
- 2017-09-04 · Mar Drugs · vol. 15 · issue 9 · p. 283
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 28 citations · more than 79% of similar papers · 1.3× the field average
- References
- 31 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Fatty Acid Research and Health · Echinoderm biology and ecology · Seaweed-derived Bioactive Compounds
- Keywords
- Eicosapentaenoic acid, Colorectal cancer, Apoptosis, Cancer research, In vivo, Cancer, Cell growth, Pharmacology, Chemistry, Medicine, Biology, Internal medicine, Fatty acid, Biochemistry
- MeSH
- hct116 cells, animals, humans, mice, mice, nude, adenocarcinoma, colorectal neoplasms, eicosapentaenoic acid, antineoplastic agents, inhibitory concentration 50, cell proliferation, female, monoglycerides, aquatic organisms
4 authors
From CA
- Caroline Morin
- Enrique Rodríguez BorjaUniversité du Québec à Rimouski
- Pierre Ulrich BlierUniversité du Québec à Rimouski
- Samuel Fortin · correspondingUniversité du Québec à Rimouski
Abstract
Background
There is increasing evidence that marine omega-3 oils are involved in the reduction of cancer risk and progression. However, the anticancer effect of omega-3 monoglyceride on colorectal cancer has yet to be assessed. The goal of this study was to evaluate the anti-cancer effects of eicosapentaenoic acid monoglyceride (MAG-EPA) in HCT116 colorectal carcinoma cells.
Methods
The effect of MAG-EPA was evaluated in vitro on HCT116 cells and in vivo on mouse model of HCT116 xenograft.
Results
Our data reveal that MAG-EPA decreased cell proliferation and induced apoptosis in HCT116 cells. In a xenograft mouse model, daily per os administration of MAG-EPA reduced tumor growth. Furthermore, MAG-EPA treatments decreased EGFR, VEGFR, and AKT activation pathways and reduced VEGF and HIF1α expression levels in tumors.
Conclusion
MAG-EPA may promote apoptosis and inhibit growth of tumors by suppressing EGFR and VEGFR activation pathways. Altogether, these data provide new evidence regarding the mode of action of MAG-EPA in colorectal cancer cells.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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