Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women
Menni C, Zierer J, Pallister T, Jackson MA, Long T, Mohney RP, Steves CJ, Spector TD, Valdes AM
Scientific reports · 184 citations
Review labels
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How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Wellcome Trust
- Government
- National Institute for Health and Care Research
- University or hospital
- King's College London
- Government
- European Commission
- University or hospital
- University of Nottingham
- Government
- National Institutes of Health
- Government
- Medical Research Council
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- National Institute for Health Research (NIHR)
- Government
- NIDDK NIH HHS
- Government
- NIH HHS
- Authors
- At least one author declares a financial tie to industry
- Grants
- Medical Research Council (FP7/20072013); Wellcome Trust (FP7/2007–2013); Medical Research Council (MR/N030125/1); National Institute for Health and Care Research (FP7/2007–2013); National Institute for Health and Care Research (NF-SI-0507-10228); National Institutes of Health (FP7/2007-2013); European Commission (2007–2013); Medical Research Council (MR/M016560/1); European Commission (FP7 2007-2013); European Commission (603946); National Institute for Health and Care Research (MR/M016560/1); European Commission (FP7/2007); European Commission (MR/M016560/1); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK093595); National Institutes of Health (1dp2od007444-01); Medical Research Council (MR/M016560/1); Wellcome Trust (MR/M016560/1); National Institute for Health and Care Research (NF-SI-0514-10027); Medical Research Council (MR/N01183X/1); National Institutes of Health (RO1 DK093595)
Based on 11 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-09-05 · Sci Rep · vol. 7 · issue 1 · p. 11079
- Publisher
- Nature Portfolio
- Cited
- 240 citations · more than 99% of similar papers · 8.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 82 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Gut microbiota and health · Metabolomics and Mass Spectrometry Studies · Diet and metabolism studies
- Keywords
- Lachnospiraceae, Microbiome, Biology, Confounding, Omega, Physiology, Food science, Metabolite, Bacteria, Biochemistry, Internal medicine, Medicine, Bioinformatics, Genetics, Firmicutes
- MeSH
- feces, humans, fatty acids, omega-3, docosahexaenoic acids, fatty acids, omega-6, glutamates, biodiversity, aged, aged, 80 and over, middle aged, female, metabolomics, metabolome, biomarkers, gastrointestinal microbiome
9 authors
From GB, DE, US
- Cristina MenniKing's College London
- Jonas ZiererKing's College London; Helmholtz Munich; Institute of Bioinformatics and Systems Biology
- Tess PallisterKing's College London
- Matthew A JacksonKing's College London
- Tao LongSanford Burnham Prebys Medical Discovery Institute
- Robert P. MohneyTriangle; Metabolon (United States)
Abstract
Omega-3 fatty acids may influence human physiological parameters in part by affecting the gut microbiome. The aim of this study was to investigate the links between omega-3 fatty acids, gut microbiome diversity and composition and faecal metabolomic profiles in middle aged and elderly women. We analysed data from 876 twins with 16S microbiome data and DHA, total omega-3, and other circulating fatty acids. Estimated food intake of omega-3 fatty acids were obtained from food frequency questionnaires. Both total omega-3and DHA serum levels were significantly correlated with microbiome alpha diversity (Shannon index) after adjusting for confounders (DHA Beta(SE) = 0.13(0.04), P = 0.0006 total omega-3: 0.13(0.04), P = 0.001). These associations remained significant after adjusting for dietary fibre intake. We found even stronger associations between DHA and 38 operational taxonomic units (OTUs), the strongest ones being with OTUs from the Lachnospiraceae family (Beta(SE) = 0.13(0.03), P = 8 × 10-7). Some of the associations with gut bacterial OTUs appear to be mediated by the abundance of the faecal metabolite N-carbamylglutamate. Our data indicate a link between omega-3 circulating levels/intake and microbiome composition independent of dietary fibre intake, particularly with bacteria of the Lachnospiraceae family. These data suggest the potential use of omega-3 supplementation to improve the microbiome composition.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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