Do nitric oxide synthase and cyclooxygenase contribute to sweating response during passive heating in endurance-trained athletes?
Amano T, Fujii N, Kenny GP, Inoue Y, Kondo N
Physiological reports · 7 citations
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Ministry of Education, Culture, Sports, Science and Technology
- Government
- Japan Society for the Promotion of Science
- Grants
- Japan Society for the Promotion of Science (16K16521)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-09-01 · Physiol Rep · vol. 5 · issue 17 · p. e13403
- Publisher
- Wiley
- Cited
- 9 citations · more than 70% of similar papers · 0.7× the field average
- References
- 38 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Thermoregulation and physiological responses · Infrared Thermography in Medicine · Exercise and Physiological Responses
- Keywords
- SWEAT, Microdialysis, Ketorolac, Nitric oxide synthase, Cyclooxygenase, Nitric oxide, Thermoregulation, Medicine, Heart rate, Internal medicine, Endocrinology, Anesthesia, Chemistry, Biochemistry, Enzyme, Blood pressure, Analgesic
- MeSH
- sweat glands, humans, ketorolac, ng-nitroarginine methyl ester, cyclooxygenase inhibitors, exercise, case-control studies, acclimatization, sweating, physical endurance, female, male, prostaglandin-endoperoxide synthases, nitric oxide synthase, hot temperature, young adult
5 authors
From JP, CA
- Tatsuro Amano · correspondingNiigata University
- Naoto FujiiUniversity of Tsukuba; Tsukuba University of Technology
- Glen Patrick KennyUniversity of Ottawa
- Yoshimitsu InoueOsaka International University
- Narihiko KondoKobe University
Abstract
The aim of our study was to determine if habitual endurance training can influence the relative contribution of nitric oxide synthase (NOS) and cyclooxygenase (COX) in the regulation of sweating during a passive heat stress in young adults. Ten trained athletes and nine untrained counterparts were passively heated until oral temperature (as estimated by sublingual temperature, Tor) increased by 1.5°C above baseline resting. Forearm sweat rate (ventilated capsule) was measured at three skin sites continuously perfused with either lactated Ringer's solution (Control), 10 mmol/L NG -nitro-L-arginine methyl ester (L-NAME, non-selective NOS inhibitor), or 10 mmol/L ketorolac (Ketorolac, non-selective COX inhibitor) via intradermal microdialysis. Sweat rate was averaged for each 0.3°C increase in Tor Sweat rate at the L-NAME site was lower than Control following a 0.9 and 1.2°C increase in Tor in both groups (all P ≤ 0.05). Relative to the Control site, NOS-inhibition reduced sweating similarly between the groups (P = 0.51). Sweat rate at the Ketorolac site was not different from the Control at any levels of Tor in both groups (P > 0.05). Nevertheless, a greater sweat rate was measured at the end of heating in the trained as compared to the untrained individuals (P ≤ 0.05). We show that NOS contributes similarly to sweating in both trained and untrained individuals during a passive heat stress. Further, no effect of COX on sweating was measured for either group. The greater sweat production observed in endurance-trained athletes is likely mediated by factors other than NOS- and COX-dependent mechanisms.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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