Funded in part by Bayer HealthCare
25-Hydroxyvitamin D deficiency and risk of MS among women in the Finnish Maternity Cohort
Munger KL, Hongell K, Åivo J, Soilu-Hänninen M, Surcel HM, Ascherio A
Neurology · 44 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Industry funded
- Company
- Bayer HealthCare
- Government
- Kela
- Government
- Terveyden ja hyvinvoinnin laitos
- Government
- National Institutes of Health
- Government
- National Institute of Neurological Disorders and Stroke
- Government
- NINDS NIH HHS
- Grants
- National Institute of Neurological Disorders and Stroke (R01 NS073633)
Based on 6 listed funder(s).
Publication
- Published
- 2017-09-14 · Neurology · vol. 89 · issue 15 · pp. 1578–1583
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 65 citations · more than 98% of similar papers · 6.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 14 works
- Access
- Open access (repository copy)
- Research areas
- Multiple Sclerosis Research Studies · Vitamin D Research Studies · Pregnancy and Medication Impact
- Keywords
- Medicine, Vitamin D and neurology, Confidence interval, Relative risk, vitamin D deficiency, Prospective cohort study, Cohort, Cohort study, Odds ratio, Logistic regression, Obstetrics, Internal medicine, Gynecology
- MeSH
- humans, multiple sclerosis, vitamin d deficiency, vitamin d, severity of illness index, case-control studies, cohort studies, age factors, pregnancy, adult, middle aged, finland, female, young adult
6 authors
From FI
- Kassandra L. MungerFinnish Institute for Health and Welfare
- Kira HongellFinnish Institute for Health and Welfare
- Julia ÅivoFinnish Institute for Health and Welfare
- Merja Soilu‐HänninenFinnish Institute for Health and Welfare
- Heljä‐Marja SurcelFinnish Institute for Health and Welfare
- Alberto AscherioFinnish Institute for Health and Welfare
Abstract
Objective
To determine whether and to what extent vitamin D deficiency is associated with multiple sclerosis (MS) risk.
Methods
We conducted a prospective nested case-control study among women in the Finnish Maternity Cohort (FMC). The FMC had 1.8 million stored serum samples taken during the pregnancies of over 800,000 women at the time of this study. Through linkages with hospital and prescription registries, we identified 1,092 women with MS diagnosed between 1983 and 2009 with at least 1 serum sample collected prior to date of MS diagnosis; ≥2 serum samples were available for 511 cases. Cases were matched to up to 3 controls (n = 2,123) on date of birth (±2 years) and area of residence. 25-Hydroxyvitamin D (25[OH]D) levels were measured using a chemiluminescence assay. We used conditional logistic regression adjusted for year of sample collection, gravidity, and parity to estimate relative risks (RRs) and 95% confidence intervals (CIs).
Results
A 50 nmol/L increase in 25(OH)D was associated with a 39% reduced risk of MS (RR 0.61, 95% CI 0.44-0.85), p = 0.003. Women with 25(OH)D levels p = 0.04) as compared to women with levels ≥50 nmol/L. In women with ≥2 samples, MS risk was 2-fold higher in women with 25(OH)D p = 0.01).
Conclusions
These results directly support vitamin D deficiency as a risk factor for MS and strengthen the rationale for broad public health interventions to improve vitamin D levels.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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