Red and processed meat intake and cancer risk: Results from the prospective NutriNet-Santé cohort study
Diallo A, Deschasaux M, Latino-Martel P, Hercberg S, Galan P, Fassier P, Allès B, Guéraud F, Pierre FH, Touvier M
International journal of cancer · 93 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- Government
- Institut National de la Santé et de la Recherche Médicale
- Government
- Ministère de la Santé
- University or hospital
- Cancéropôle Ile de France
- Government
- Institut National de la Recherche Agronomique
- University or hospital
- Université Paris 13
- Government
- Institut de Veille Sanitaire
- University or hospital
- Conservatoire National des Arts et Métiers
Based on 7 listed funder(s).
Publication
- Published
- 2017-09-15 · Int J Cancer · vol. 142 · issue 2 · pp. 230–237
- Publisher
- Wiley
- Cited
- 144 citations · more than 99% of similar papers · 10.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 42 works
- Access
- Open access (hybrid journal) · OTHER-OA
- Research areas
- Nutritional Studies and Diet · Consumer Attitudes and Food Labeling · Nutrition, Genetics, and Disease
- Keywords
- Medicine, Red meat, Prospective cohort study, Prostate cancer, Breast cancer, Cancer, Processed meat, Colorectal cancer, Cohort study, Internal medicine, Cohort, Gynecology, Pathology, Food science, Biology
- MeSH
- humans, neoplasms, neoplasm staging, prognosis, risk factors, follow-up studies, prospective studies, nutritional status, meat products, middle aged, female, male, red meat
10 authors
From FR
- Abou Diallo · correspondingInserm; Université Paris Cité; Université Sorbonne Paris Nord; Sorbonne Paris Cité; Hôpital Avicenne; Centre de Recherche Épidémiologie et Statistique
- Mélanie DeschasauxInserm; Université Paris Cité; Université Sorbonne Paris Nord; Sorbonne Paris Cité; Centre de Recherche Épidémiologie et Statistique
- Paule Latino‐MartelInserm; Université Paris Cité; Université Sorbonne Paris Nord; Sorbonne Paris Cité; Centre de Recherche Épidémiologie et Statistique
- Serge HerçbergInserm; Université Paris Cité; Université Sorbonne Paris Nord; Sorbonne Paris Cité; Hôpital Avicenne; Centre de Recherche Épidémiologie et Statistique
- Pilar GalánInserm; Université Paris Cité; Université Sorbonne Paris Nord; Sorbonne Paris Cité; Centre de Recherche Épidémiologie et Statistique
- Philippine FassierInserm; Université Paris Cité; Université Sorbonne Paris Nord; Sorbonne Paris Cité; Centre de Recherche Épidémiologie et Statistique
Abstract
The International Agency for Research on Cancer (WHO-IARC) classified red meat and processed meat as probably carcinogenic and carcinogenic for humans, respectively. These conclusions were mainly based on studies concerning colorectal cancer, but scientific evidence is still limited for other cancer locations. In this study, we investigated the prospective associations between red and processed meat intakes and overall, breast, and prostate cancer risk. This prospective study included 61,476 men and women of the French NutriNet-Santé cohort (2009-2015) aged ≥35 y and who completed at least three 24 hrs dietary records during the first year of follow-up. The risk of developing cancer was compared across sex-specific quintiles of red and processed meat intakes by multivariable Cox models. 1,609 first primary incident cancer cases were diagnosed during follow-up, among which 544 breast cancers and 222 prostate cancers. Red meat intake was associated with increased risk of overall cancers [HRQ5vs.Q1 =1.31 (1.10-1.55), ptrend = 0.01) and breast cancer (HRQ5vs.Q1 = 1.83 (1.33-2.51), ptrend = 0.002]. The latter association was observed in both premenopausal [HRQ5vs.Q1 =2.04 (1.03-4.06)] and postmenopausal women [HRQ5vs.Q1 =1.79 (1.26-2.55)]. No association was observed between red meat intake and prostate cancer risk. Processed meat intake was relatively low in this study (cut-offs for the 5th quintile = 46 g/d in men and 29 g/d in women) and was not associated with overall, breast or prostate cancer risk. This large cohort study suggested that red meat may be involved carcinogenesis at several cancer locations (other than colon-rectum), in particular breast cancer. These results are consistent with mechanistic evidence from experimental studies.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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