The Effect of Improved Serum 25-Hydroxyvitamin D Status on Glycemic Control in Diabetic Patients: A Meta-Analysis
Mirhosseini N, Vatanparast H, Mazidi M, Kimball SM
The Journal of clinical endocrinology and metabolism · 96 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Chinese Academy of Sciences
Based on 1 listed funder(s).
Publication
- Published
- 2017-07-03 · J Clin Endocrinol Metab · vol. 102 · issue 9 · pp. 3097–3110
- Publisher
- Oxford University Press
- Cited
- 159 citations · more than 95% of similar papers · 3.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 97 works
- Access
- Free to read
- Research areas
- Vitamin D Research Studies · HIV-related health complications and treatments · Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- Medicine, Glycemic, Internal medicine, Vitamin D and neurology, Cochrane Library, Insulin resistance, Confidence interval, Meta-analysis, Type 2 diabetes, Gastroenterology, Diabetes mellitus, Randomized controlled trial, Glycated hemoglobin, Hemoglobin, Insulin, Endocrinology
- MeSH
- humans, diabetes mellitus, type 2, vitamin d deficiency, blood glucose, vitamin d, hypoglycemic agents, dietary supplements, glycated hemoglobin
4 authors
From CA, CN
- Naghmeh Zahra MirhosseiniPure North
- Hassanali VatanparastUniversity of Saskatchewan
- Mohsen MazidiChinese Academy of Sciences; Institute of Genetics and Developmental Biology; University of Chinese Academy of Sciences
- Samantha Kimball · correspondingPure North; St. Mary's University
Abstract
Background
Type 2 diabetes is a global health concern, with an increased prevalence and high cost of treatment.
Objective
The aim of this systematic review and meta-analysis was to determine the effect of vitamin D supplementation and improved vitamin D status on glycemia and insulin resistance in type 2 diabetic patients.
Data source
We searched PUBMED/Medline, Cumulative Index to Nursing and Allied Health, and Cochrane Library (until January 2017).
Study selection
Prospective clinical trials were selected evaluating the impact of vitamin D supplementation on glycosylated hemoglobin (HbA1c), serum fasting plasma glucose (FPG), and homeostatic model assessment of insulin resistance (HOMA-IR) in diabetic patients.
Data extraction and synthesis
We used a random-effects model to synthesize quantitative data, followed by a leave-one-out method for sensitivity analysis. The systematic review registration was CRD42017059555. From a total of 844 entries identified via literature search, 24 controlled trials (1528 individuals diagnosed with type 2 diabetes) were included. The meta-analysis indicated a significant reduction in HbA1c [mean difference: -0.30%; 95% confidence interval (CI): -0.45 to -0.15, P < 0.001], FPG [mean difference: -4.9 mg/dL (-0.27 mmol/L); 95% CI: -8.1 to -1.6 (-0.45 to -0.09 mmol/L), P = 0.003], and HOMA-IR (mean difference: -0.66; 95% CI: -1.06 to -0.26, P = 0.001) following vitamin D supplementation and significant increase in serum 25-hydroxyvitamin D levels [overall increase of 17 ± 2.4 ng/mL (42 ± 6 nmol/L)].
Conclusions
Vitamin D supplementation, a minimum dose of 100 µg/d (4000 IU/d), may significantly reduce serum FPG, HbA1c, and HOMA-IR index, and helps to control glycemic response and improve insulin sensitivity in type 2 diabetic patients.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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