Plasma 25-hydroxyvitamin D levels, vitamin D intake, and pancreatic cancer risk or mortality: a meta-analysis
Zhang X, Huang XZ, Chen WJ, Wu J, Chen Y, Wu CC, Wang ZN
Oncotarget · 33 citations
How it was studied
- Design
- Meta-analysis (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- University or hospital
- Wenzhou Medical University
- University or hospital
- China Medical University
- University or hospital
- Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-06-29 · Oncotarget · vol. 8 · issue 38 · pp. 64395–64406
- Publisher
- Impact Journals LLC
- Cited
- 44 citations · more than 68% of similar papers · 0.9× the field average
- References
- 82 works
- Access
- Open access (free to publish) · CC-BY
- Research areas
- Vitamin D Research Studies · Vitamin C and Antioxidants Research · GDF15 and Related Biomarkers
- Keywords
- Medicine, Vitamin D and neurology, Meta-analysis, Pancreatic cancer, Internal medicine, Cancer, Oncology, Endocrinology, Gastroenterology
7 authors
From CN
- Xi Zhang · correspondingWenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- Xuanzhang Huang · correspondingWenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- Wen-jun ChenWenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- Jian WuWenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
- You Chen
- Cong-cong WuWenzhou Medical University; Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
Abstract
Background
The associations between vitamin D status, including plasma 25-hydroxyvitamin D [25(OH)D] levels and vitamin D intake, and pancreatic cancer risk and mortality are inconsistent. The aims of this study are to evaluate the antitumor and therapeutic effects of vitamin D status for pancreatic cancer patients.
Methods
A literature search for relevant studies was conducted using PubMed and Embase databases. Risk ratio (RR), hazard ratio (HR), and 95% confidence interval (CI) were used as the effect measures. All statistical analyses were performed using Stata software 12.0.
Results
Our results indicated that high plasma 25(OH)D levels were inversely associated with pancreatic cancer mortality without significant heterogeneity (HR=0.81, 95% CI=0.68-0.96). However, high plasma 25(OH)D levels could not reduce pancreatic cancer risk (RR=1.02, 95% CI=0.66-1.57). Moreover, vitamin D intake was also not associated with pancreatic cancer risk (RR=1.11, 95% CI=0.67-1.86).
Conclusions
Our results indicate that high plasma 25(OH)D levels were significantly associated with improved survival in pancreatic cancer patients. However, there were no significant associations between vitamin D intake or plasma 25(OH)D levels and pancreatic cancer risk.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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