Funded in part by Novo Nordisk, Novo Nordisk Fonden
Vitamin D Stored in Fat Tissue During a 5-Year Intervention Affects Serum 25-Hydroxyvitamin D Levels the Following Year
Martinaityte I, Kamycheva E, Didriksen A, Jakobsen J, Jorde R
The Journal of clinical endocrinology and metabolism · 57 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- University or hospital
- Universitetet i Tromsø
- Company
- Novo Nordisk
- Government
- Norges Forskningsråd
- Nonprofit
- Diabetesforbundet
- Company
- Novo Nordisk Fonden
- Grants
- Norges Forskningsråd (184766); Novo Nordisk Fonden (NNF12OC1016126); Novo Nordisk (R195-A16126)
Based on 5 listed funder(s).
Publication
- Published
- 2017-07-26 · J Clin Endocrinol Metab · vol. 102 · issue 10 · pp. 3731–3738
- Publisher
- Oxford University Press
- Cited
- 74 citations · more than 94% of similar papers · 3.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 26 works
- Access
- Free to read
- Research areas
- Vitamin D Research Studies · Adipokines, Inflammation, and Metabolic Diseases · HIV-related health complications and treatments
- Keywords
- Vitamin D and neurology, Vitamin, Intervention (counseling), Medicine, Physiology, Internal medicine, Endocrinology, Chemistry, Nursing
- MeSH
- adipose tissue, humans, diabetes mellitus, type 2, vitamin d deficiency, vitamin d, placebos, follow-up studies, double-blind method, time factors, dietary supplements, aged, aged, 80 and over, middle aged, female, male
5 authors
From NO, DK
- Ieva Martinaityte · correspondingUniversity Hospital of North Norway; UiT The Arctic University of Norway
- Elena KamychevaUniversity Hospital of North Norway; UiT The Arctic University of Norway
- Allan DidriksenUiT The Arctic University of Norway
- Jette JakobsenTechnical University of Denmark
- Rolf JordeUniversity Hospital of North Norway; UiT The Arctic University of Norway
Abstract
Context
Vitamin D and 25-hydroxyvitamin D [25(OH)D] are stored in adipose tissue, but the clinical relevance is uncertain.
Objective
To evaluate changes in serum 25(OH)D and adipose tissue vitamin D levels after stopping vitamin D supplementation.
Design
A prospective, double-blind cohort follow-up study.
Setting
Clinical Research Unit at University Hospital of North Norway.
Patients
Seventy-six subjects were included after participation in a 3- to 5-year prevention of type 2 diabetes study and were administered 20,000 IU of vitamin D or placebo per week.
Intervention
During the 12-month follow-up period, blood samples were drawn at the beginning and after 1, 3, 6, 9, and 12 months. Fat biopsies were taken at the start and end.
Main outcome measures
Changes in 25(OH)D level in serum and 25(OH)D and vitamin D levels in adipose tissue.
Results
Forty-one of 42 subjects who were given vitamin D and 33 of 34 subjects who were given placebo completed the study. At the inclusion, mean serum 25(OH)D levels were 122 and 71 nmol/L in the vitamin D and placebo groups, respectively. Serum 25(OH)D levels were significantly higher in the vitamin D group than in the placebo group throughout and were 84.5 and 73.1 nmol/L, respectively, after 12 months. In the vitamin D group, adipose tissue vitamin D levels decreased by 52% over 12 months.
Conclusion
Vitamin D and 25(OH)D stored in adipose tissue after 3 to 5 years of vitamin D supplementation may have a clinically relevant effect on serum 25(OH)D level the following year.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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