Modulation of the gut microbiota by the mixture of fish oil and krill oil in high-fat diet-induced obesity mice
Cui C, Li Y, Gao H, Zhang H, Han J, Zhang D, Li Y, Zhou J, Lu C, Su X
PloS one · 51 citations
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Ningbo University
- Unclassified
- Nature
- University or hospital
- K. C. Wong Magna Fund in Ningbo University
- University or hospital
- Talent project in Ningbo University
- University or hospital
- K.C.Wong Magna Fund in Ningbo University
- Government
- Key Specialty of Ningbo City
Based on 6 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-10-09 · PLoS One · vol. 12 · issue 10 · p. e0186216
- Publisher
- Public Library of Science
- Cited
- 70 citations · more than 94% of similar papers · 3.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 80 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Gut microbiota and health · Diet and metabolism studies · Nutritional Studies and Diet
- Keywords
- Gut flora, Obesity, Fish oil, Triglyceride, Krill, Biology, Food science, Fatty liver, Internal medicine, Endocrinology, Cholesterol, Physiology, Biochemistry, Fish <Actinopterygii>, Medicine, Ecology, Fishery
- MeSH
- liver, animals, humans, mice, mice, obese, euphausiacea, obesity, cholesterol, triglycerides, lipoproteins, ldl, fish oils, diet, high-fat, gastrointestinal microbiome
10 authors
From CN, US
- Chenxi CuiNingbo University
- Yanyan LiNingbo University; Cornell University
- Hang GaoFirst Bethune Hospital of Jilin University
- Hongyan ZhangNingbo University
- Jiaojiao HanNingbo University
- Dijun ZhangNingbo University
Abstract
Previous studies confirmed that dietary supplements of fish oil and krill oil can alleviate obesity in mice, but the underlying mechanism remains unclear. This study aims to discern whether oil treatment change the structure of the gut microbiota during the obesity alleviation. The ICR mice received high-fat diet (HFD) continuously for 12 weeks after two weeks of acclimatization with a standard chow diet, and the mice fed with a standard chow diet were used as the control. In the groups that received HFD with oil supplementation, the weight gains were attenuated and the liver index, total cholesterol, triglyceride and low-density lipoprotein cholesterol were reduced stepwise compared with the HFD group, and the overall structure of the gut microbiota, which was modulated in the HFD group, was shifted toward the structure found in the control group. Moreover, eighty-two altered operational taxonomic units responsive to oil treatment were identified and nineteen of them differing in one or more parameters associated with obesity. In conclusion, this study confirmed the effect of oil treatment on obesity alleviation, as well as on the microbiota structure alterations. We proposed that further researches are needed to elucidate the causal relationship between obesity alleviation and gut microbiota modulation.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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