Different Protocols of Photobiomodulation Therapy of Hyposalivation
Brzak BL, Cigić L, Baričević M, Sabol I, Mravak-Stipetić M, Risović D
Photomedicine and laser surgery · 31 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2017-10-12 · Photomed Laser Surg · vol. 36 · issue 2 · pp. 78–82
- Publisher
- Mary Ann Liebert, Inc.
- Cited
- 41 citations · more than 87% of similar papers · 2.2× the field average
- References
- 28 works
- Access
- Open access (repository copy) · OTHER-OA
- Research areas
- Laser Applications in Dentistry and Medicine · Salivary Gland Disorders and Functions · Oral health in cancer treatment
- Keywords
- Medicine, Saliva, Low level laser therapy, Laser therapy, Clinical study, Clinical trial, Dentistry, Internal medicine, Laser
- MeSH
- salivary glands, humans, xerostomia, treatment outcome, radiotherapy dosage, risk assessment, follow-up studies, dose-response relationship, radiation, salivation, time factors, aged, aged, 80 and over, middle aged, female, low-level light therapy
6 authors
From HR, CN
- Božana Lončar BrzakUniversity of Zagreb
- Livia CigićUniversity of Split
- Marinka BaričevićUniversity of Applied Health Sciences
- Ivan SabolRuđer Bošković Institute
- Marinka Mravak‐Stipetić · correspondingUniversity of Zagreb
- Dubravko RisovićRuđer Bošković Institute; Centre of Excellence for Advanced Materials
Abstract
Objective
Photobiomodulation (PBM) therapy has proved to be effective for a wide range of oral pathologies including oral dryness, but the literature still lacks reports of clinical trials and protocols. The purpose of our study was to evaluate the effects of different wavelengths of PBM on salivation in patients suffering from hyposalivation aiming at determination of optimal treatment protocol.
Materials and methods
This study included 30 patients whose major salivary glands were treated with low-intensity diode laser BTL2000 (Medical Technologies, s.r.o., Czech Republic) during 10 consecutive days. Patients were randomly assigned into two groups, each of 15 patients, and treated with PBM of 830 nm and PBM of 685 nm, respectively. The whole unstimulated and stimulated saliva quantities were measured each day during 10 days, before and after laser treatment, and at 10th day after treatment was ended.
Results
Results have shown that the laser treatment significantly improves salivation (p < 0.0001) in both groups after 10 days treatment. The salivation also remains improved 10 days after the end of treatment. The patients treated with PBM of 830 nm have had continuously higher values of quantity of saliva.
Conclusions
Our results have shown that both laser wavelengths were effective in increasing salivary flow rate, and the improvement in salivation was statistically significant. The effect of treatment could be observed 10 days after the completion of treatment, thus providing evidence not only of stimulative effect but also indicating regenerative potential of PBM therapy.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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