The effects of EPA and DHA enriched fish oil on nutritional and immunological markers of treatment naïve breast cancer patients: a randomized double-blind controlled trial
Paixão EMDS, Oliveira ACM, Pizato N, Muniz-Junqueira MI, Magalhães KG, Nakano EY, Ito MK
Nutrition journal · 69 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Government
- Fundação de Apoio à Pesquisa do Distrito Federal
- Grants
- Fundação de Apoio à Pesquisa do Distrito Federal (0193.000.557/2009)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-10-23 · Nutr J · vol. 16 · issue 1 · p. 71
- Publisher
- BioMed Central
- Cited
- 91 citations · more than 94% of similar papers · 3.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 38 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Fatty Acid Research and Health · Coconut Research and Applications · Natural Products and Biological Research
- Keywords
- Fish oil, Medicine, Docosahexaenoic acid, Eicosapentaenoic acid, Clinical nutrition, Internal medicine, Breast cancer, Gastroenterology, Polyunsaturated fatty acid, Proinflammatory cytokine, Randomized controlled trial, Endocrinology, Cancer, Inflammation, Fatty acid, Biochemistry, Biology, Fish <Actinopterygii>
- MeSH
- cd4-positive t-lymphocytes, humans, breast neoplasms, docosahexaenoic acids, eicosapentaenoic acid, dinoprostone, fish oils, c-reactive protein, cytokines, diet, double-blind method, nutritional status, socioeconomic factors, adolescent, adult, aged, middle aged, female, young adult, biomarkers
7 authors
From BR
- Elemárcia Martins da Silva Paixão · correspondingUniversidade de Brasília
- Ana Carolina de M. OliveiraUniversidade de Brasília
- Nathalia PizatoUniversidade de Brasília
- Maria Imaculada Muniz‐JunqueiraUniversidade de Brasília
- Kelly Grace MagalhãesUniversidade de Brasília
- Eduardo Yoshio NakanoUniversidade de Brasília
Abstract
Background
We evaluated the effects of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids enriched fish oil (FO) on nutritional and immunological parameters of treatment naïve breast cancer patients.
Methods
In a randomized double blind controlled trial, the FO group (FG) patients were supplemented with 2 g/ day of FO concentrate containing 1.8 g of n-3 fatty acids during 30 days. The placebo group (PG) received 2 g/ day of mineral oil. At baseline and after the intervention, plasma levels of n-3 fatty acids, dietary intake, weight, body composition, biochemical and immunological markers were assessed.
Results
At the end of the intervention period, no between group differences were observed regarding anthropometric parameters. There was a significant increase in the plasma phospholipid EPA (p = 0.004), DHA (p = 0.007) of the FG patients. In FG patients the percentages of peripheral blood CD4+ T lymphocytes and serum high sensitivity C-reactive protein (hsCRP) levels were maintained while in PG patients there was a significant increase in hsCRP (p = 0.024). We also observed a significant reduction in the percentage of CD4+ T lymphocytes in the peripheral blood (p = 0.042) of PG patients. No changes in serum proinflammatory cytokine and prostaglandin E2 levels were observed.
Conclusions
Supplementation of newly diagnosed breast cancer patients with EPA and DHA led to a significant change in the composition of plasma fatty acids, maintained the level of CD4+ T cells and serum levels of hsCRP, suggestive of a beneficial effect on the immune system and less active inflammatory response.
Trial registration
Brazilian Clinical Trials Registry (REBEC): RBR-2b2hqh. Registered 29 April 2013, retrospectively registered.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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