Polyphenol- and Caffeine-Rich Postfermented Pu-erh Tea Improves Diet-Induced Metabolic Syndrome by Remodeling Intestinal Homeostasis in Mice
Gao X, Xie Q, Kong P, Liu L, Sun S, Xiong B, Huang B, Yan L, Sheng J, Xiang H
Infection and immunity · 80 citations
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Jilin Province Science and Technology Institute of China
- Government
- Jilin Province Development and Reform Commission of China
Based on 2 listed funder(s).
Publication
- Published
- 2017-10-24 · Infect Immun · vol. 86 · issue 1
- Publisher
- American Society for Microbiology
- Cited
- 128 citations · more than 96% of similar papers · 5.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 56 works
- Access
- Open access (repository copy)
- Research areas
- Tea Polyphenols and Effects · Gut microbiota and health · Tryptophan and brain disorders
- Keywords
- Akkermansia muciniphila, Gut flora, Biology, Endocrinology, Akkermansia, Internal medicine, Diet-induced obese, Lipid metabolism, Metabolic syndrome, Thermogenesis, Brown adipose tissue, Faecalibacterium prausnitzii, Glucose homeostasis, White adipose tissue, Biochemistry, Adipose tissue, Insulin resistance, Lactobacillus, Obesity, Medicine, Fermentation
- MeSH
- intestines, liver, cell line, cell line, tumor, hela cells, animals, mice, inbred c57bl, humans, mice, endotoxemia, inflammation, caffeine, homeostasis, tea, male, lipid metabolism, hek293 cells, polyphenols, diet, high-fat, microbiota, gastrointestinal microbiome, metabolic syndrome
10 authors
From CN
- Xiaoyu GaoJilin University; Puer University
- Qiuhong XieJilin University
- Ping Hao KongJilin University
- Ling LiuJilin University
- Sheng Nan SunJilin University
- Boyu XiongJilin University
Abstract
Postfermented Pu-erh tea (PE) protects against metabolic syndrome (MS), but little is known regarding its underlying mechanisms. Animal experiments were performed to determine whether the gut microbiota mediated the improvement in diet-induced MS by PE and its main active components (PEAC). We confirmed that PE altered the body composition and energy efficiency, attenuated metabolic endotoxemia and systemic and multiple-tissue inflammation, and improved the glucose and lipid metabolism disorder in high-fat diet (HFD)-fed mice via multiple pathways. Notably, PE promoted the lipid oxidation and browning of white adipose tissue (WAT) in HFD-fed mice. Polyphenols and caffeine (CAF) played critical roles in improving these parameters. Meanwhile, PE remodeled the disrupted intestinal homeostasis that was induced by the HFD. Many metabolic changes observed in the mice were significantly correlated with alterations in specific gut bacteria. Akkermansia muciniphila and Faecalibacterium prausnitzii were speculated to be the key gut bacterial links between the PEAC treatment and MS at the genus and species levels. Interestingly, A. muciniphila administration altered body composition and energy efficiency, promoted the browning of WAT, and improved the lipid and glucose metabolism disorder in the HFD-fed mice, whereas F. prausnitzii administration reduced the HFD-induced liver and intestinal inflammatory responses. In summary, polyphenol- and CAF-rich PE improved diet-induced MS, and this effect was associated with a remodeling of the gut microbiota.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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