Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity
Norris JM, Lee HS, Frederiksen B, Erlund I, Uusitalo U, Yang J, Lernmark Å, Simell O, Toppari J, Rewers M, Ziegler AG, She JX, Onengut-Gumuscu S, Chen WM, Rich SS, Sundvall J, Akolkar B, Krischer J, Virtanen SM, Hagopian W, TEDDY Study Group
Diabetes · 85 citations
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- Centers for Disease Control and Prevention
- Government
- National Institute of Allergy and Infectious Diseases
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- National Institute of Environmental Health Sciences
- Government
- National Center for Advancing Translational Sciences
- Government
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Government
- NIDDK NIH HHS
- Nonprofit
- JDRF
- Government
- NCATS NIH HHS
- Grants
- National Institute of Diabetes and Digestive and Kidney Diseases (UC4-DK-112243); National Institute of Diabetes and Digestive and Kidney Diseases (HHSN267200700014C); National Institute of Diabetes and Digestive and Kidney Diseases (U01 DK63865); National Institute of Diabetes and Digestive and Kidney Diseases (UC4-DK-117483); National Institute of Diabetes and Digestive and Kidney Diseases (U01-DK-063829); National Center for Advancing Translational Sciences (UL 1 TR001082); National Institute of Diabetes and Digestive and Kidney Diseases (U01-DK-63821); National Institute of Diabetes and Digestive and Kidney Diseases (UC4 DK106955); National Institute of Diabetes and Digestive and Kidney Diseases (UC4 DK063865); National Center for Advancing Translational Sciences (UL1-TR001427); National Institute of Diabetes and Digestive and Kidney Diseases (P30‐DK‐017047); National Institute of Diabetes and Digestive and Kidney Diseases (UC4 DK063861); National Institute of Diabetes and Digestive and Kidney Diseases (UC4 DK063829); National Center for Advancing Translational Sciences (UL1 TR 000064); National Institute of Diabetes and Digestive and Kidney Diseases (U01DK063865); National Institute of Diabetes and Digestive and Kidney Diseases (U01DK63829); National Institute of Diabetes and Digestive and Kidney Diseases (UC4 DK095300); National Institute of Diabetes and Digestive and Kidney Diseases (U01DK63861); National Institute of Diabetes and Digestive and Kidney Diseases (UC4-DK-100238); National Institute of Diabetes and Digestive and Kidney Diseases (U01 DK63861, U01 DK63821); National Institute of Diabetes and Digestive and Kidney Diseases (U01 DK063790); National Institute of Diabetes and Digestive and Kidney Diseases (U01 DK063863); National Institute of Diabetes and Digestive and Kidney Diseases (U01 DK063861); National Institute of Diabetes and Digestive and Kidney Diseases (UC4 DK063821); National Institute of Diabetes and Digestive and Kidney Diseases (UC4 DK063863); National Institute of Diabetes and Digestive and Kidney Diseases (UC4 DK063836); National Institute of Diabetes and Digestive and Kidney Diseases (U01 DK063836); National Institute of Diabetes and Digestive and Kidney Diseases (U01 DK063821)
Based on 9 listed funder(s).
Publication
- Published
- 2017-10-23 · Diabetes · vol. 67 · issue 1 · pp. 146–154
- Publisher
- American Diabetes Association
- Cited
- 116 citations · more than 98% of similar papers · 7.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 55 works
- Access
- Open access (repository copy)
- Research areas
- Vitamin D Research Studies · Diabetes and associated disorders · Digestive system and related health
- Keywords
- Vitamin D and neurology, Calcitriol receptor, Internal medicine, Endocrinology, Odds ratio, Medicine, Diabetes mellitus, Type 1 diabetes, Allele, Case-control study, vitamin D deficiency, Autoimmunity, Gastroenterology, Biology, Gene, Genetics, Disease
- MeSH
- humans, diabetes mellitus, type 1, genetic predisposition to disease, vitamin d, case-control studies, autoimmunity, polymorphism, single nucleotide, infant, infant, newborn, female, male
100 authors
From US, FI, SE, DE
- Jill M. Norris · correspondingColorado School of Public Health; University of Colorado Anschutz
- Jill M. NorrisColorado School of Public Health; University of South Florida; University of Colorado Anschutz
- Hye‐Seung LeeColorado School of Public Health; University of South Florida; University of Colorado Anschutz
- Brittni FrederiksenColorado School of Public Health; Finnish Institute for Health and Welfare; University of Colorado Anschutz
- Iris ErlundUniversity of South Florida; Finnish Institute for Health and Welfare
- Ulla UusitaloUniversity of South Florida
Abstract
We examined the association between plasma 25-hydroxyvitamin D [25(OH)D] concentration and islet autoimmunity (IA) and whether vitamin D gene polymorphisms modify the effect of 25(OH)D on IA risk. We followed 8,676 children at increased genetic risk of type 1 diabetes at six sites in the U.S. and Europe. We defined IA as positivity for at least one autoantibody (GADA, IAA, or IA-2A) on two or more visits. We conducted a risk set sampled nested case-control study of 376 IA case subjects and up to 3 control subjects per case subject. 25(OH)D concentration was measured on all samples prior to, and including, the first IA positive visit. Nine polymorphisms in VDR, CYP24A, CYP27B1, GC, and RXRA were analyzed as effect modifiers of 25(OH)D. Adjusting for HLA-DR-DQ and ancestry, higher childhood 25(OH)D was associated with lower IA risk (odds ratio = 0.93 for a 5 nmol/L difference; 95% CI 0.89, 0.97). Moreover, this association was modified by VDR rs7975232 (interaction P = 0.0072), where increased childhood 25(OH)D was associated with a decreasing IA risk based upon number of minor alleles: 0 (1.00; 0.93, 1.07), 1 (0.92; 0.89, 0.96), and 2 (0.86; 0.80, 0.92). Vitamin D and VDR may have a combined role in IA development in children at increased genetic risk for type 1 diabetes.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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