Cruciferous and Allium Vegetable Intakes are Inversely Associated With 15-Year Atherosclerotic Vascular Disease Deaths in Older Adult Women
Blekkenhorst LC, Bondonno CP, Lewis JR, Devine A, Zhu K, Lim WH, Woodman RJ, Beilin LJ, Prince RL, Hodgson JM
Journal of the American Heart Association · 44 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Healthway
- Government
- Medical Research Council
- Government
- National Health and Medical Research Council
- Grants
- National Health and Medical Research Council (572604); National Health and Medical Research Council (1084922); National Health and Medical Research Council (254627, 303169 and 572604); National Health and Medical Research Council (303169); Healthway (572604); Healthway (254627); Healthway (303169); National Health and Medical Research Council (254627)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-10-11 · J Am Heart Assoc · vol. 6 · issue 10
- Publisher
- Wiley
- Cited
- 57 citations · more than 97% of similar papers · 7.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 55 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Nutritional Studies and Diet · Garlic and Onion Studies · Antioxidant Activity and Oxidative Stress
- Keywords
- Cruciferous vegetables, Medicine, Disease, Gerontology, Internal medicine, Cancer
- MeSH
- humans, brassicaceae, allium, vegetables, prognosis, multivariate analysis, proportional hazards models, risk factors, chi-square distribution, longitudinal studies, prospective studies, risk reduction behavior, age factors, sex factors, nutritional status, nutritive value, time factors, aged, western australia, female, atherosclerosis, phytochemicals, recommended dietary allowances, protective factors, diet, healthy
10 authors
From AU
- Lauren C. BlekkenhorstThe University of Western Australia; Royal Perth Hospital
- Catherine P. BondonnoEdith Cowan University; The University of Western Australia; Royal Perth Hospital
- Joshua Richard LewisThe University of Sydney; The University of Western Australia; Children's Hospital at Westmead; Queen Elizabeth II Medical Centre
- Amanda DevineEdith Cowan University
- Kun ZhuThe University of Western Australia; Sir Charles Gairdner Hospital; Queen Elizabeth II Medical Centre
- Wai H. LimThe University of Western Australia; Sir Charles Gairdner Hospital; Queen Elizabeth II Medical Centre
Abstract
Background
Higher vegetable intake is consistently associated with lower atherosclerotic vascular disease (ASVD) events. However, the components responsible and mechanisms involved are uncertain. Nonnutritive phytochemicals may be involved. The objective of this study was to investigate the associations of total vegetable intake and types of vegetables grouped according to phytochemical constituents with ASVD mortality.
Methods and results
The cohort consisted of 1226 Australian women aged 70 years and older without clinical ASVD or diabetes mellitus at baseline (1998). Vegetable intakes were calculated per serving (75 g/d) and were also classified into prespecified types relating to phytochemical constituents. ASVD-related deaths were ascertained from linked mortality data. During 15 years (15 947 person-years) of follow-up, 238 ASVD-related deaths occurred. A 1-serving increment of vegetable intake was associated with a 20% lower hazard of ASVD-related death (multivariable-adjusted hazard ratio, 0.80; 95% confidence interval, 0.69-0.94 [P=0.005]). In multivariable-adjusted models for vegetable types, cruciferous (per 10-g/d increase: hazard ratio, 0.87; 95% confidence interval, 0.81-0.94 [PP=0.003]) vegetables were inversely associated with ASVD-related deaths. The inclusion of other vegetable types, as well as lifestyle and cardiovascular risk factors, did not alter these associations. Yellow/orange/red (P=0.463), leafy green (P=0.063), and legume (P=0.379) vegetables were not significant.
Conclusions
Consistent with current evidence, higher cruciferous and allium vegetable intakes were associated with a lower risk of ASVD mortality. In addition, cruciferous and allium vegetables are recognized to be a good source of several nonnutritive phytochemicals such as organosulfur compounds.
Clinical trial registration
URL: http://www.anzctr.org.au. Unique identifier: ACTRN12617000640303.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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