Physiological serum 25-hydroxyvitamin D concentrations are associated with improved thyroid function-observations from a community-based program
Mirhosseini N, Brunel L, Muscogiuri G, Kimball S
Endocrine · 42 citations
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2017-10-24 · Endocrine · vol. 58 · issue 3 · pp. 563–573
- Publisher
- Springer Science+Business Media
- Cited
- 60 citations · more than 92% of similar papers · 3.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 52 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Thyroid Disorders and Treatments · Thyroid Cancer Diagnosis and Treatment
- Keywords
- Euthyroid, Subclinical infection, Medicine, Vitamin D and neurology, Thyroid function, Internal medicine, Endocrinology, Thyroid, vitamin D deficiency, Thyroid disease, Diabetes mellitus, Thyroid function tests
- MeSH
- thyroid gland, humans, vitamin d deficiency, hypothyroidism, vitamins, vitamin d, immunoglobulins, thyroid-stimulating, thyroid function tests, case-control studies, follow-up studies, nutritional status, dietary supplements, databases, factual, adolescent, adult, aged, aged, 80 and over, middle aged, health promotion, community health services, female, male
4 authors
From CA
- Naghmeh Zahra MirhosseiniPure North
- Ludovic Brunel
- Giovanna Muscogiuri
- Samantha Kimball · correspondingSt. Mary's University
Abstract
Purpose
Vitamin D deficiency has been associated with an increased risk of hypothyroidism and autoimmune thyroid disease. Our aim was to investigate the influence of vitamin D supplementation on thyroid function and anti-thyroid antibody levels.
Methods
We constructed a database that included 11,017 participants in a health and wellness program that provided vitamin D supplementation to target physiological serum 25-hydroxyvitmain D [25(OH)D] concentrations (>100 nmol/L). Participant measures were compared between entry to the program (baseline) and follow-up (12 ± 3 months later) using an intent-to-treat analysis. Further, a nested case-control design was utilized to examine differences in thyroid function over 1 year in hypothyroid individuals and euthyroid controls.
Results
More than 72% of participants achieved serum 25(OH)D concentrations >100 nmol/L at follow-up, with 20% above 125 nmol/L. Hypothyroidism was detected in 2% (23% including subclinical hypothyroidism) of participants at baseline and 0.4% (or 6% with subclinical) at follow-up. Serum 25(OH)D concentrations ≥125 nmol/L were associated with a 30% reduced risk of hypothyroidism and a 32% reduced risk of elevated anti-thyroid antibodies. Hypothyroid cases were found to have higher mean serum 25(OH)D concentrations at follow-up, which was a significant positive predictor of improved thyroid function.
Conclusion
The results of the current study suggest that optimal thyroid function might require serum 25(OH)D concentrations above 125 nmol/L. Vitamin D supplementation may offer a safe and economical approach to improve thyroid function and may provide protection from developing thyroid disease.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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