Safety and Effectiveness of Low-Level Laser Therapy in Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis
Rayegani SM, Raeissadat SA, Heidari S, Moradi-Joo M
Journal of lasers in medical sciences · 67 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2017-08-29 · J Lasers Med Sci · vol. 8 · issue Suppl 1 · pp. S12–S19
- Cited
- 98 citations · more than 87% of similar papers · 2.0× the field average
- References
- 30 works
- Access
- Open access (free to publish) · CC-BY-NC
- Research areas
- Osteoarthritis Treatment and Mechanisms · Laser Applications in Dentistry and Medicine · Shoulder Injury and Treatment
- Keywords
- Medicine, WOMAC, Osteoarthritis, Meta-analysis, Low level laser therapy, Placebo, Physical therapy, Range of motion, Randomized controlled trial, Laser therapy, Internal medicine, Alternative medicine
4 authors
From IR
- Seyed Mansour RayeganiShahid Beheshti University of Medical Sciences
- Seyed Ahmad RaeissadatShahid Beheshti University of Medical Sciences
- Saeed Heidari KeshelKermanshah University of Medical Sciences
- Mohammad Moradi-JooIran Meteorological Organization; Shahid Beheshti University of Medical Sciences
Abstract
Introduction: Low-level laser therapy (LLLT) was introduced as an alternative non-invasive treatment for osteoarthritis, but its effectiveness is still controversial. The main objective of this article was to determine the safety and efficacy of LLLT in patients with knee osteoarthritis (KOA). Methods: In order to gather evidence, main medical databases as well as relevant websites were browsed without time limit. We searched with appropriate keywords and strategies. After quality assessment of studies, study data were extracted by two reviewers. Standard mean difference proposed through inverse variance was used in the meta-analysis using the random-effects model. Twelve values were used for the evaluation of heterogeneity. Results: A total of 823 studies, 14 randomized controlled trials (RCTs) were selected after final review. There was a significant difference between LLLT and placebo in pain at rest (P=0.02), pain at activity (P=0.01), total pain (P=0.03), WOMAC function (P=0.01), WOMAC stiffness (P=0.02) and WOMAC total (PP=0.09) and range of motion (P=0.1). Conclusion: In spite of some positive findings, this meta-analysis lacked data on how LLLT effectiveness is affected with important factors: wavelength, energy density, treatment duration, numbers of sessions the treatment, severity of KOA and site of application.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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