Cutaneous reactive hyperaemia is unaltered by dietary nitrate supplementation in healthy humans
Wong BJ, Keen JT, Levitt EL
Clinical physiology and functional imaging · 6 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- University of Kansas
Based on 1 listed funder(s).
Publication
- Published
- 2017-10-29 · Clin Physiol Funct Imaging · vol. 38 · issue 5 · pp. 772–778
- Publisher
- Wiley
- Cited
- 8 citations · more than 68% of similar papers · 0.6× the field average
- References
- 53 works
- Access
- Paywalled
- Research areas
- Thermoregulation and physiological responses · Nitric Oxide and Endothelin Effects · Heart Rate Variability and Autonomic Control
- Keywords
- Hyperaemia, Medicine, Blood pressure, Reactive hyperemia, Vasodilation, Laser Doppler velocimetry, Nitrate, Microdialysis, Internal medicine, C-reactive protein, Blood flow, Anesthesia, Cardiology, Endocrinology, Chemistry, Inflammation
- MeSH
- microcirculation, skin, humans, beta vulgaris, plant roots, hyperemia, nitrates, blood flow velocity, laser-doppler flowmetry, blood pressure, regional blood flow, vasodilation, time factors, dietary supplements, adult, female, male, young adult, healthy volunteers, fruit and vegetable juices
3 authors
From US
- Brett James Wong · correspondingGeorgia State University; Kansas State University
- Jeremy Thomas KeenKansas State University
- Erica Lynne LevittKansas State University
Abstract
The purpose of this study was to determine whether nitrate supplementation augments cutaneous reactive hyperaemia. Seven participants were tested pre- and postnitrate supplementation (25 ml beetroot juice); participants consumed one shot per day for 3 days. Participants were instrumented with two microdialysis fibres: control (Ringer's solution) and NO synthase inhibition (20 mM L-NAME). Skin blood flow was measured via laser-Doppler flowmetry (LDF). A blood pressure cuff was placed on the experimental arm and inflated to 250 mmHg for 5 mins to occlude arterial inflow. The cuff was released, and the resultant reactive hyperaemia was measured. Blood pressure was continuously measured via plethysmography from a finger on the non-experimental arm. Cutaneous vascular conductance was calculated (LDF/MAP) and normalized to maximal vasodilatation (%CVCmax ). Only diastolic blood pressure was reduced following nitrate supplementation (71 ± 2 vs. 66 ± 1 mmHg; Pmax ) or L-NAME (Pre: 52 ± 2 vs. Post: 59 ± 4%CVCmax ) sites. There was no effect of nitrate supplementation on total reactive hyperaemia at either control (Pre: 4197 ± 943 vs. Post: 4523 ± 1040%CVCmax * sec) or L-NAME (Pre: 5108 ± 997 vs. Post: 5694 ± 1002%CVCmax * sec) sites. These data suggest cutaneous reactive hyperaemia is unaffected by dietary nitrate supplementation in healthy humans.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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