Association between egg consumption and cardiovascular disease events, diabetes and all-cause mortality
Guo J, Hobbs DA, Cockcroft JR, Elwood PC, Pickering JE, Lovegrove JA, Givens DI
European journal of nutrition · 40 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- University of Bristol
- Nonprofit
- Barham Benevolent Foundation
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-11-02 · Eur J Nutr · vol. 57 · issue 8 · pp. 2943–2952
- Publisher
- Springer Science+Business Media
- Cited
- 53 citations · more than 95% of similar papers · 4.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 42 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Consumer Attitudes and Food Labeling · Phytoestrogen effects and research
- Keywords
- Diabetes mellitus, Disease, Medicine, Consumption (sociology), Environmental health, Type 2 diabetes, Internal medicine, Endocrinology
- MeSH
- humans, cardiovascular diseases, diabetes mellitus, type 2, glucose intolerance, blood glucose, body mass index, diet, nutrition assessment, incidence, mortality, risk factors, follow-up studies, prospective studies, cross-sectional studies, eggs, adult, middle aged, male, young adult
7 authors
From GB
- Jing GuoUniversity of Reading
- Ditte A. HobbsUniversity of Reading
- John R. CockcroftCardiff University; Cardiff Metropolitan University
- P C ElwoodCardiff University
- Janet E. PickeringUniversity of Reading
- Julie Anne Lovegrove · correspondingUniversity of Reading
Abstract
Purpose
The association between egg consumption and cardiovascular disease (CVD) or type 2 diabetes (T2D) remains controversial. We investigated the association between egg consumption and risk of CVD (primary outcome), T2D and mortality in the Caerphilly prospective cohort study (CAPS) and National Diet and Nutritional Survey (NDNS).
Methods
CAPS included 2512 men aged 45-59 years (1979-1983). Dietary intake, disease incidence and mortality were updated at 5-year intervals. NDNS included 754 adults aged 19-64 years from 2008 to 2012.
Results
Men free of CVD (n = 1781) were followed up for a mean of 22.8 years, egg consumption was not associated with new incidence of CVD (n = 715), mortality (n = 1028) or T2D (n = 120). When stroke (n = 248), MI (n = 477), heart failure (n = 201) were investigated separately, no associations between egg consumption and stroke and MI were identified, however, increased risk of stroke in subjects with T2D and/or impaired glucose tolerance (IGT, fasting plasma glucose ≥ 6.1 mmol/L), adjusted hazard ratios (95% CI) were 1.0 (reference), 1.09 (0.41, 2.88), 0.96 (0.37, 2.50), 1.39 (0.54, 3.56) and 2.87 (1.13, 7.27) for egg intake (n) of 0 ≤ n ≤ 1, 1 < n ≤ 2, 2 < n ≤ 3, 3 < n < 5, and n ≥ 5 eggs/wk, respectively (P = 0.01). In addition, cross-sectional analyses revealed that higher egg consumption was significantly associated with elevated fasting glucose in those with T2D and/or IGT (CAPS: baseline P = 0.02 and 5-year P = 0.04; NDNS: P = 0.05).
Conclusions
Higher egg consumption was associated with higher blood glucose in subjects with T2D and/or IGT. The increased incidence of stroke with higher egg consumption among T2D and/or IGT sub-group warrants further investigation.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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