Acute and chronic cold exposure differentially affects the browning of porcine white adipose tissue
Gao Y, Qimuge NR, Qin J, Cai R, Li X, Chu GY, Pang WJ, Yang GS
Animal : an international journal of animal bioscience · 27 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- National Science and Technology Major Project
- Grants
- National Natural Science Foundation of China (31572366); National Science and Technology Major Project (2016ZX08006-003); National Natural Science Foundation of China (2016ZX08006-003); National Natural Science Foundation of China (2015CB943102)
Based on 2 listed funder(s).
Publication
- Published
- 2017-11-16 · Animal · vol. 12 · issue 7 · pp. 1435–1441
- Publisher
- Elsevier BV
- Cited
- 39 citations · more than 82% of similar papers · 1.5× the field average
- References
- 30 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Adipose Tissue and Metabolism · Exercise and Physiological Responses · Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- Browning, Thermogenesis, Thermogenin, White adipose tissue, Brown adipose tissue, Mitochondrial biogenesis, Adipose tissue, PRDM16, Endocrinology, Uncoupling protein, Internal medicine, Biology, Chemistry, Biochemistry, Medicine, Mitochondrion
- MeSH
- animals, swine, humans, thermogenesis, subcutaneous fat, adipose tissue, white, cold temperature, uncoupling protein 1
8 authors
From CN
- Yanbin GaoNorth West Agriculture and Forestry University; Northwest A&F University
- Naren QimugeNorth West Agriculture and Forestry University; Northwest A&F University
- Jing QinNorth West Agriculture and Forestry University; Northwest A&F University
- Rui CaiNorth West Agriculture and Forestry University; Northwest A&F University
- X. LiNorth West Agriculture and Forestry University; Northwest A&F University
- Guiyan ChuNorth West Agriculture and Forestry University; Northwest A&F University
Abstract
Piglets are characteristically cold intolerant and thus susceptible to high mortality. However, browning of white adipose tissue (WAT) can induce non-shivering thermogenesis as a potential strategy to facilitate the animal's response to cold. Whether cold exposure can induce browning of subcutaneous WAT (sWAT) in piglets in a similar manner as it can in humans remains largely unknown. In this study, piglets were exposed to acute cold (4°C, 10 h) or chronic cold exposure (8°C, 15 days), and the genes and proteins of uncoupling protein 1 (UCP1)-dependent and independent thermogenesis, mitochondrial biogenesis, lipogenic and lipolytic processes were analysed. Interestingly, acute cold exposure induced browning of porcine sWAT, smaller adipocytes and the upregulated expression of UCP1, PGC1α, PGC1β, C/EBPβ, Cidea, UCP3, CKMT1 and PM20D1. Conversely, chronic cold exposure impaired the browning process, reduced mitochondrial numbers and the expression of browning markers, including UCP1, PGC1α and PRDM16. The present study demonstrated that acute cold exposure (but not chronic cold exposure) induces porcine sWAT browning. Thus, browning of porcine sWAT could be a novel strategy to balance the body temperature of piglets, and thus could be protective against cold exposure.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.