Funded in part by International Nut and Dried Fruit Council
The effect of nut consumption on markers of inflammation and endothelial function: a systematic review and meta-analysis of randomised controlled trials
Neale EP, Tapsell LC, Guan V, Batterham MJ
BMJ open · 86 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
- Government
- Australian Government
- Industry group
- International Nut and Dried Fruit Council
- University or hospital
- Illawarra Health and Medical Research Institute
Based on 3 listed funder(s).
Publication
- Published
- 2017-11-01 · BMJ Open · vol. 7 · issue 11 · p. e016863
- Publisher
- BMJ
- Cited
- 114 citations · more than 83% of similar papers · 1.0× the field average
- References
- 83 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Nuts composition and effects · Peanut Plant Research Studies · Antioxidant Activity and Oxidative Stress
- Keywords
- Medicine, Meta-analysis, Randomized controlled trial, Internal medicine, Cochrane Library, Systematic review, Adiponectin, Clinical trial, Prospective cohort study, Nut, MEDLINE, Obesity, Insulin resistance
- MeSH
- brachial artery, humans, nuts, inflammation, c-reactive protein, cytokines, blood flow velocity, diet, randomized controlled trials as topic, biomarkers
4 authors
From AU
- Elizabeth Phillipa Neale · correspondingUniversity of Wollongong; Illawarra Health and Medical Research Institute
- Linda C TapsellUniversity of Wollongong; Illawarra Health and Medical Research Institute
- Vivienne X. GuanUniversity of Wollongong
- Marijka Jane BatterhamUniversity of Wollongong
Abstract
Objectives
To examine the effect of nut consumption on inflammatory biomarkers and endothelial function.
Design
A systematic review and meta-analysis.
Data sources
MEDLINE, PubMed, Cumulative Index to Nursing and Allied Health Literature and Cochrane Central Register of Controlled Trials (all years to 13 January 2017).
Eligibility criteria
Randomised controlled trials (with a duration of 3 weeks or more) or prospective cohort designs conducted in adults; studies assessing the effect of consumption of tree nuts or peanuts on C-reactive protein (CRP), adiponectin, tumour necrosis factor alpha, interleukin-6, intercellular adhesion molecule 1, vascular cell adhesion protein 1 and flow-mediated dilation (FMD).
Data extraction and analysis
Relevant data were extracted for summary tables and analyses by two independent researchers. Random effects meta-analyses were conducted to explore weighted mean differences (WMD) in change or final mean values for each outcome.
Results
A total of 32 studies (all randomised controlled trials) were included in the review. The effect of nut consumption on FMD was explored in nine strata from eight studies (involving 652 participants), with consumption of nuts resulting in significant improvements in FMD (WMD: 0.79%(95% CI 0.35 to 1.23)). Nut consumption resulted in small, non-significant differences in CRP (WMD: -0.01 mg/L (95% CI -0.06 to 0.03)) (26 strata from 25 studies), although sensitivity analyses suggest results for CRP may have been influenced by two individual studies. Small, non-significant differences were also found for other biomarkers of inflammation.
Conclusions
This systematic review and meta-analysis of the effects of nut consumption on inflammation and endothelial function found evidence for favourable effects on FMD, a measure of endothelial function. Non-significant changes in other biomarkers indicate a lack of consistent evidence for effects of nut consumption on inflammation. The findings of this analysis suggest a need for more research in this area, with a particular focus on randomised controlled trials.
Prospero registration number
CRD42016045424.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.