Association between serum concentration of 25-hydroxyvitamin D and community-acquired pneumonia: a case-control study
Mamani M, Muceli N, Ghasemi Basir HR, Vasheghani M, Poorolajal J
International journal of general medicine · 38 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2017-11-01 · Int J Gen Med · vol. Volume 10 · pp. 423–429
- Publisher
- Dove Medical Press
- Cited
- 70 citations · more than 95% of similar papers · 4.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 39 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Vitamin D Research Studies · Pneumocystis jirovecii pneumonia detection and treatment · Vitamin C and Antioxidants Research
- Keywords
- Medicine, Vitamin D and neurology, vitamin D deficiency, Pneumonia, Internal medicine, Intensive care unit, Incidence (geometry), Community-acquired pneumonia, Population, Case-control study, Population study, Gastroenterology, Pediatrics
5 authors
From IR
- Mojgan MamaniHamedan University of Medical Sciences
- Neda MuceliHamedan University of Medical Sciences
- Hamid Reza Ghasemi BasirHamedan University of Medical Sciences
- Maryam VasheghaniMasih Daneshvari Hospital; Shahid Beheshti University of Medical Sciences
- Jalal PoorolajalHamedan University of Medical Sciences
Abstract
Background
Community-acquired pneumonia (CAP) is a common disease with significant morbidity and mortality. There is evidence that vitamin D deficiency can be associated with infectious diseases. The aim of this study was to compare the levels of vitamin D between patients with CAP and healthy controls.
Methods
In a case-control study on 73 patients with CAP and 76 healthy controls, the serum concentration of 25-hydroxyvitamin D (25[OH]D) was measured. Severity and outcomes of disease and also duration of hospital stay were compared in patients with different levels of 25(OH)D. The severity of CAP was assessed using the CURB-65 score (confusion, uremia, respiratory rate, low blood pressure, age ≥65 years) and was also reflected by the length of hospital stay, admission to intensive care unit (ICU), and 30-day mortality.
Results
In total, 81.2% of the study population had vitamin D levels P=0.006). Prevalence of severe deficiency of vitamin D in scores three and four of CURB-65 (59.38%), was far more than scores one and two (31.71%). Also, results indicated patients with severe deficiency had a higher risk for ICU admission, 30-day mortality, and longer hospitalization stay, but these were not statistically significant.
Conclusion
According to findings, a low level of 25(OH)D is associated with a higher incidence of CAP and more severe disease. It is recommended to pay more attention to vitamin D deficiency in infectious diseases, particularly in CAP patients.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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