Fasting conditions: Influence of water intake on clinical chemistry analytes
Benozzi SF, Unger G, Campion A, Pennacchiotti GL
Biochemia medica · 5 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2017-11-23 · Biochem Med (Zagreb) · vol. 28 · issue 1 · p. 010702
- Publisher
- Croatian society of medical biochemistry and laboratory medicine
- Cited
- 15 citations · more than 64% of similar papers · 0.4× the field average
- References
- 34 works
- Access
- Open access (free to publish) · CC-BY
- Research areas
- Clinical Laboratory Practices and Quality Control · Renal function and acid-base balance · Blood properties and coagulation
- Keywords
- Internal medicine, Chemistry, Creatinine, Uric acid, Triglyceride, Urea, Bilirubin, Cholesterol, Endocrinology, Phlebotomy, Hemoglobin, Medicine, Animal science, Biochemistry, Biology
- MeSH
- humans, water, cholesterol, l-lactate dehydrogenase, gamma-glutamyltransferase, triglycerides, fasting, drinking, chemistry, clinical, adult, middle aged, female, young adult
4 authors
From AR
- Silvia Fabiana BenozziUniversidad Nacional del Sur
- Gisela UngerUniversidad Nacional del Sur
- Amparo CampionUniversidad Nacional del Sur
- Graciela Laura PennacchiottiUniversidad Nacional del Sur
Abstract
Introduction
Currently available recommendations regarding fasting requirements before phlebotomy do not specify any maximum water intake volume permitted during the fasting period. The aim was to study the effects of 300 mL water intake 1 h before phlebotomy on specific analytes.
Materials and methods
Blood was collected from 20 women (median age (min-max): 24 (22 - 50) years) in basal state (T0) and 1 h after 300 mL water intake (T1). Glucose, total proteins (TP), urea, creatinine, cystatin C, total bilirubin (BT), total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides (Tg), uric acid (UA), high-sensitivity C-reactive protein, gamma-glutamyl transferase (GGT), aspartate-aminotransferase (AST), alanine-aminotransferase and lactate-dehydrogenase (LD) were studied. Results were analyzed using Wilcoxon test. Mean difference (%) was calculated for each analyte and was further compared with reference change value (RCV). Only mean differences (%) higher than RCV were considered clinically significant.
Results
Significant differences (median T0vs median T1, P) were observed for TP (73 vs 74 g/L, 0.001); urea (4.08 vs 4.16 mmol/L, 0.010); BT (12 vs 13 µmol/L, 0.021); total cholesterol (4.9 vs 4.9 mmol/L, 0.042); Tg (1.05 vs 1.06 mmol/L, 0.002); UA (260 vs 270 µmol/L, 0.006); GGT (12 vs 12 U/L, 0.046); AST (22 vs 24 U/L, 0.001); and LD (364 vs 386 U/L, 0.001). Although the differences observed were statistically significant, they were not indicative of clinically significant changes.
Conclusions
A water intake of 300 mL 1 h prior to phlebotomy does not interfere with the analytes studied in the present work.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.