Beneficial effects of oral pure caffeine on oxidative stress
Metro D, Cernaro V, Santoro D, Papa M, Buemi M, Benvenga S, Manasseri L
Journal of clinical & translational endocrinology · 45 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2017-10-14 · J Clin Transl Endocrinol · vol. 10 · pp. 22–27
- Publisher
- Elsevier BV
- Cited
- 73 citations · more than 96% of similar papers · 5.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 85 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Coffee research and impacts · Tea Polyphenols and Effects · Coenzyme Q10 studies and effects
- Keywords
- Oxidative stress, Caffeine, Medicine, Pharmacology, Internal medicine
7 authors
From IT
- Daniela MetroUniversity of Messina
- Valeria CernaroUniversity of Messina
- Domenico Santoro · correspondingUniversity of Messina
- Mattia PapaUniversity of Messina
- Michele BuemiUniversity of Messina
- Salvatore BenvengaUniversity of Messina; Azienda Ospedaliera Universitaria Policlinico "G. Martino"
Abstract
Ingestion of coffee (which is a mixture of over 1000 hydrosoluble substances) is known to protect from type-2 diabetes mellitus and its complications, and other chronic disorders associated with increased oxidative damage in blood and tissues. This protection is generally attributed to polyphenols and melanoidins. Very few studies were conducted on the amelioration of classic blood markers of oxidative stress induced after a few days of caffeine administration, but results vary. To assess whether caffeine per se could account for antioxidant properties of coffee in the short-term, we tested the ability of pure caffeine ingestion (5 mg/kg body weight/day in two daily doses for seven consecutive days) to improve plasma levels of six biochemical indices in healthy male volunteers (n = 15). These indices were total antioxidant capacity (TAC), glutathione (GSH), oxidized glutathione (GSSG), GSH to GSSG ratio, lipid hydroperoxides (LOOH) and malondialdehyde (MDA). We found that all indices changed significantly (P < .05 or < .01) in a favourable manner, ranging from -41% for GSSG to -70% for LHP levels, and +106% for GSH levels to +249% for the GSG/GSSG ratio. Changes of any given index were uniform across subjects, with no outliers. We conclude that caffeine has unequivocal, consistent antioxidant properties.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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