Evaluating the effects of administration of 25-hydroxyvitamin D supplement on serum anti-mullerian hormone (AMH) levels in infertile women
Naderi Z, Kashanian M, Chenari L, Sheikhansari N
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 22 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2017-12-06 · Gynecol Endocrinol · vol. 34 · issue 5 · pp. 409–412
- Publisher
- Informa
- Cited
- 49 citations · more than 84% of similar papers · 1.7× the field average
- References
- 35 works
- Access
- Paywalled
- Research areas
- Vitamin D Research Studies · Ovarian function and disorders · Menstrual Health and Disorders
- Keywords
- Anti-Müllerian hormone, Medicine, Hormone, Internal medicine, Infertility, Vitamin D and neurology, Endocrinology, Ovarian reserve, Serum concentration, Significant difference, Gynecology, Pregnancy, Biology
- MeSH
- humans, infertility, female, vitamin d, treatment outcome, dietary supplements, adult, female, anti-mullerian hormone
4 authors
From IR, GB
- Zahra NaderiIran University of Medical Sciences
- Maryam Kashanian · correspondingIran University of Medical Sciences
- Leily ChenariIran University of Medical Sciences
- Narges SheikhansariUniversity of Southampton
Abstract
The aim of the study was to evaluate the effects of administration of 25-hydroxyvitamin D [25(OH) D] on serum antimullerian hormone (AMH) levels in infertile women. The study was performed as a non-randomized clinical trial on 30 infertile women who had low serum level of both 25(OH) D and anti-mullerian hormone. Vitamin D was prescribed 50,000 IU weekly for up to three months for all eligible participants. Serum levels of both 25(OH) D and AMH have increased significantly after treatment with 25(OH) D. There was a significant correlation between serum levels of 25(OH) D after treatment with AMH (p = .029, OR = 2.9, CI 95% = 2.7-5.5). Mean AMH level after treatment was higher in women with sufficient 25(OH) D, than women with insufficient 25(OH) D (1.048 ± 0.644 vs. 0.513 ± 0.284 ng/ml), which shows a significant difference (p = .043). Also, after treatment, in women with mean AMH level of >0.7 ng/ml (19 women), mean level of 25(OH) D was higher than in women with mean AMH level of <0.7 ng/ml (11 women) (59.332 ± 21.751 vs. 38.881 ± 17.281 ng/ml, p = .013). This means that higher levels of 25(OH) D are accompanied with higher levels of AMH. In conclusions with administration and increasing the amount of vitamin D serum levels, the serum levels of AMH have increased.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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