Effect of oral magnesium supplementation on the transcription of TRPM6, TRPM7, and SLC41A1 in individuals newly diagnosed of pre-hypertension. A randomized, double-blind, placebo-controlled trial
Rodríguez-Ramírez M, Rodríguez-Morán M, Reyes-Romero MA, Guerrero-Romero F
Magnesium research · 11 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2017-07-01 · Magnes Res · vol. 30 · issue 3 · pp. 80–87
- Publisher
- John Libbey Eurotext
- Cited
- 12 citations · more than 78% of similar papers · 1.1× the field average
- References
- 0 works
- Access
- Paywalled
- Research areas
- Magnesium in Health and Disease
- Keywords
- Placebo, Magnesium, Medicine, Internal medicine, Gastroenterology, Endocrinology, Blood pressure, Chemistry, Pathology
- MeSH
- humans, magnesium, cation transport proteins, double-blind method, blood pressure, adult, aged, middle aged, female, male, trpm cation channels, prehypertension, protein serine-threonine kinases
4 authors
From MX
- Mariana Rodríguez-RamírezMexican Social Security Institute; Durango Institute of Technology
- Martha Rodríguez‐MoránMexican Social Security Institute; Durango Institute of Technology
- Miguel Arturo Reyes-RomeroAutonomous University of Durango
- Fernando Guerrero‐RomeroMexican Social Security Institute; Durango Institute of Technology
Abstract
A stringent regulation of influx and efflux of magnesium by cation transporters seems to play an important role in the regulation of blood pressure (BP). With this regard, we evaluate the effect of oral magnesium supplementation on the transcription of TRPM6, TRPM7, and SLC41A1, in individuals with incident pre-hypertension (preHTN). For such purpose, we conducted a randomized, double-blind, placebo-controlled trial that compared 18 individuals who received oral magnesium lactate (360 mg elemental magnesium) versus 18 individuals who received placebo, during 4 months. Diagnosis of hypertension or normal BP, diabetes, alcohol intake, chronic diarrhea, use of diuretics, intake of magnesium supplementation, and reduced renal function were exclusion criteria. Regarding the transcription analysis of TRPM6, TRPM7, and SLC41A1 using RT-qPCR, leukocyte-rich plasma was obtained and total RNA was isolated with the kit Direct-zol™ RNA MiniPrep (Zymo). The leukocyte TRPM6 mRNA relative expression showed a significant increase (2.1 ± 1.37 and 0.8 ± 0.4, P<0.05), whereas the mRNA relative expression of both leukocyte TRPM7 (0.8 ± 1.1 and 0.9 ± 0.6, pNS) and SLC41A1 (0.9 ± 1.0 and 0.7 ± 0.6, pNS) showed no significant differences, between the magnesium and placebo groups, respectively. Oral magnesium supplementation increases the leukocyte TRPM6 mRNA relative expression, in subjects with new diagnosis of preHTN.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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