Plasma Alkylresorcinol Metabolite, a Biomarker of Whole-Grain Wheat and Rye Intake, and Risk of Type 2 Diabetes and Impaired Glucose Regulation in a Chinese Population
Sun T, Rong Y, Hu X, Zhu Y, Huang H, Chen L, Li P, Li S, Yang W, Cheng J, Yang X, Yao P, Hu FB, Liu L
Diabetes care · 22 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Intake biomarkers
Who paid for it
- Funding
- Independent funding
- Government
- Fundamental Research Funds for the Central Universities
- Government
- Technique Innovation Program (Major Program) of Hubei Province of China
- University or hospital
- Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College, Huazhong University of Science and Technology
- Grants
- Fundamental Research Funds for the Central Universities (HUST 2016YXMS219)
Based on 3 listed funder(s).
Publication
- Published
- 2017-12-20 · Diabetes Care · vol. 41 · issue 3 · pp. 440–445
- Publisher
- American Diabetes Association
- Cited
- 32 citations · more than 90% of similar papers · 2.6× the field average
- References
- 41 works
- Access
- Paywalled
- Research areas
- Food composition and properties · Metabolomics and Mass Spectrometry Studies · Liver Disease Diagnosis and Treatment
- Keywords
- Medicine, Internal medicine, Type 2 diabetes, Diabetes mellitus, Odds ratio, Body mass index, Family history, Quartile, Population, Biomarker, Endocrinology, Confidence interval, Biology, Environmental health
- MeSH
- humans, triticum, diabetes mellitus, type 2, glucose intolerance, phenylpropionates, resorcinols, diet, risk factors, case-control studies, prospective studies, adult, aged, middle aged, china, female, male, biomarkers, secale
14 authors
From CN, US
- Taoping SunHuazhong University of Science and Technology
- Rong YingShandong University; Shandong Provincial Hospital
- Xiaoli HuHuazhong University of Science and Technology
- Yalun ZhuHuazhong University of Science and Technology
- Hao HuangHuazhong University of Science and Technology
- Liangkai ChenHuazhong University of Science and Technology
Abstract
Objective
To examine the association of plasma alkylresorcinol metabolite 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), a biomarker of whole-grain wheat and rye intake, with type 2 diabetes (T2D) and impaired glucose regulation (IGR) in a Chinese population.
Research design and methods
A total of 1,060 newly diagnosed T2D patients, 736 newly diagnosed IGR patients, and 1,443 control subjects with normal glucose tolerance were recruited in the case-control study. Plasma DHPPA concentrations were determined by high-performance liquid chromatography-tandem mass spectroscopy. Multivariate logistic regression analysis was used to evaluate the independent association of plasma DHPPA concentrations with the likelihood of T2D and IGR.
Results
After adjustment for age, sex, BMI, and family history of diabetes, the odds ratios (95% CI) of T2D and IGR were 0.57 (0.45, 0.73) and 0.66 (0.50, 0.85), respectively, comparing the lowest with the highest quartile of plasma DHPPA concentrations. Further adjustment for current smoking status, current alcohol consumption, physical activity, history of hypertension, and educational level did not change the observed association materially. Similar results were also obtained in T2D and IGR groups combined. The inverse association of plasma DHPPA with T2D persisted in stratified analyses according to age, sex, BMI, current smoking status, current alcohol consumption, physical activity, family history of diabetes, and history of hypertension.
Conclusions
These findings suggested that higher plasma DHPPA concentrations were associated with lower odds of T2D and IGR. Further studies are warranted to confirm these findings in prospective cohorts.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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