Magnesium intake and mortality due to liver diseases: Results from the Third National Health and Nutrition Examination Survey Cohort
Wu L, Zhu X, Fan L, Kabagambe EK, Song Y, Tao M, Zhong X, Hou L, Shrubsole MJ, Liu J, Dai Q
Scientific reports · 38 citations
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- U.S. Department of Health and Human Services
- Government
- National Cancer Institute
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NIDDK NIH HHS
- Government
- NCI NIH HHS
- Grants
- National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK-058404); National Cancer Institute (R01 CA202936)
Based on 5 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-12-14 · Sci Rep · vol. 7 · issue 1 · p. 17913
- Publisher
- Nature Portfolio
- Cited
- 57 citations · more than 89% of similar papers · 2.4× the field average
- References
- 41 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments
- Keywords
- National Health and Nutrition Examination Survey, Cohort, Medicine, Environmental health, Cohort study, Gerontology, Internal medicine, Population
- MeSH
- humans, fatty liver, magnesium deficiency, magnesium, nutrition surveys, nutritional status, adult, middle aged, united states, female, male
11 authors
From CN, US
- Lijun WuFudan University; Huashan Hospital
- Xiangzhu ZhuVanderbilt University; Vanderbilt University Medical Center
- Lei FanShanghai University of Traditional Chinese Medicine; Longhua Hospital Shanghai University of Traditional Chinese Medicine
- Edmond Kato KabagambeVanderbilt University Medical Center
- Yiqing SongIndiana University – Purdue University Indianapolis
- Meng‐Hua TaoUniversity of North Texas; University of North Texas Health Science Center
Abstract
People with fatty liver disease are at high risk of magnesium deficiency. Meanwhile, low magnesium status is linked to both chronic inflammation and insulin resistance. However, no study has investigated the association between intake of magnesium and risk of mortality due to liver diseases. We evaluated the association between total magnesium intake and mortality due to liver diseases in the Third National Health and Nutrition Examination Study (NHANES III) cohort, which included 13,504 participants who completed liver ultrasound examination for hepatic steatosis. Overall magnesium intake was associated with a reduced risk of mortality due to liver disease at borderline significance (P = 0.05). In fully-adjusted analyses, every 100 mg increase in intake of magnesium was associated with a 49% reduction in the risk for mortality due to liver diseases. Although interactions between magnesium intake and alcohol use and hepatic steatosis at baseline were not significant (P > 0.05), inverse associations between magnesium intake and liver disease mortality were stronger among alcohol drinkers and those with hepatic steatosis. Our findings suggest higher intakes of magnesium may be associated with a reduced risk of mortality due to liver disease particularly among alcohol drinkers and those with hepatic steatosis. Further studies are warranted to confirm the findings.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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